Fibrin matrices

Upon resolntion of the pathogen, the second phase of wonnd healing occurs where re-epithelialization and neovascularization are essential for wound closure. Formation of new blood vessels (angiogenesis) (Barcelos et al. 2005 Roy et al. 2008), fibrin matrices (Midwood et al. 2006), and collagen deposits (Seppinen et al. 2008) are all events that promote the wound closure process. 

Koolwijk P, Sidenius N, Peters E, Sier CF, Hanemaaijer R, Blasi F, et al. Proteolysis of the urokinase-type plasminogen activator receptor by metalloproteinase-12 Implication for angiogenesis in fibrin matrices. Blood 2001 97(10) 3123—3131. 

Schmoekel H, Schense JC, Weber FE, Gratz KW, Gnagi D, Muller R, and Hubbell JA. Bone Healing in the Rat and Dog with Nonglycosylated BMP-2 Demonstrating Low Solubility in Fibrin Matrices./ Orthop Res 2004 22 (2) 376-381. 

Jason C. Schense, Jecelyne Bloch, Patrick Aebischer and Jeffrey A. Hubbell, Enzymatic incoipora-tion of bioactive peptides into fibrin matrices enhances neurite extension. Nature Biotechnology, 18 (2000), 415 19. 

Zisch A H, et al. (2001). Covalently conjugated VEGF—fibrin matrices for endothe-lialization. J. Control. Rel. 72 101-113. 

Zisch, A. H., Schenk, U., Schense, J. C., Sakiyama-Elbert, S. E., and Hubbell, J. A. (2001), Covalently conjugated VEGF-fibrin matrices for endothelialization, J. Control Release 72(1-3) 101-113. 

Zisch, A.H. et al.. Covalently conjugated VEGF-fibrin matrices for endothelialization, /. Control. Release , 101-13,2001. 

Schense, J.C., Bloch, J., Aebischer, R, and HubbeU, J.A., Enzymatic incorporation of bioactive peptides into fibrin matrices enhances neurite extension, Nat. Biotechnol 18,415-419, 2000. 

Wood, M. D., M. R. Macewan, A. R. French et al. 2010. Fibrin matrices with affinity-based debvery systems and neurotrophic factors promote functional nerve regeneration. Biotechnol Bioeng 106 970-79. 

Wood, M. D., A. M. Moore, D. A. Hunter et al. 2009. Affinity-based release of glial-derived neurotrophic factor from fibrin matrices enhances sciatic nerve regeneration. Acta Biomater 5 959-68. 

Zisch AH, Schenk U, Schense JC, Saki3rama-Elbert SE, Hubbell JA [2001]. Covalentty conjugated VEGF—fibrin matrices for endothelialization. J Control Release, 72,101-113. 

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