Protein fibrillar

Veerman, C. (2004) Properties of fibrillar protein assemblies and their percolating networks. PhD Thesis, Wageningen University, the Netherlands. 

In this condition monoclonal immunoglobulins are produced due to a clonal disorder of either plasma cells or lymphocytes. Light chains produced are more frequently of the A than the k type (A7, S17). The monoclonal immunoglobulins produced could be either IgG, IgA, IgM, or IgD. The deposition of a fibrillar protein, most often k light chains, in many tissues is referred to as amyloidosis. The deposition of A. light chains alone is referred to as primary amyloidosis. 

A comparison of thermodynamic data on denaturation of globular proteins with that of fibrillar proteins and melting of phospholipid membranes led to a conclusion that the van der Waals contribution to the stabilization of protein structure is of the same order as that of hydrogen bonds (Priva-lov, 1982 see also Crigbaum and Komoria, 1979a,b). 

Tropomyosin and troponin. Tropomyosin is apparently the most stable of the fish fibrillar proteins during frozen storage. It can be extracted long after actin and myosin become inextract-able however, it does denature gradually (90). 

The hbrillary astrocytoma is more common than the protoplasmic astrocytoma. " Fibrillary astrocytomas are a mixture of cellular processes (fibrils) and nuclei of greater angularity and density than normal or reactive astrocytes (Fig. 20.13 see Fig. 20.1 IB). They contain more intracytoplasmic fibrils, and their cellular processes are longer than those in protoplasmic astrocytomas. Thus, only the fibrillary astrocytoma stains well with phosphotungstic acid hematoxylin (PTAH), which stains fibrillar protein arrays, whereas both... 

Amyloidosis is a condition which is characterized by the extracellular deposition of abnormal fibrillar proteins (amyloid), in amounts sufficient to impair correct organ function. Typical examples include Alzhei-mef s disease and prion disease. 

Amyloidosis is a term encompassing many diseases that share a common feature— the extracellular deposition of pathologic insoluble fibrillar proteins called amyloid in organs and tissues. In Amy Lloyd s disease, amyloidosis/AL, the amyloid is derived from immunoglobulin light chains (AL = amyloidosis, light-chain related). 

Isoelectric Predpitalion Zone and Isoelectric Point of the Fibrillar Proteins... 

Bendall, J. R., and Wismer-Pedersen, J. (1%2). Some properties of the fibrillar proteins of normal and watery pork muscle. J. Food ScL 27,144. 

Oriented films of poly-a-L-glutamic acid and its esters were examined in 1951 via X-ray analysis by Pauling and Corey [26]. The reflexions related to a spacing of 1.5 A, observed also by other investigators at about the same time, confirmed the existence of an a-helix predicted by Pauling et al. [27] for fibrillar proteins, (see Plate 34). 

Each molecule of a given protein shows the same sequence, as determined by these methods. However, fibrillar proteins do not necessarily appear to follow this rule. 

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