Fibrillar collagens formation

OrvimU, Roald HE, Stqrhens RW, Roos N, Sakariassen KS Tissue factor-induced coagulation triggers platelet thrombus formation as effidently as fibrillar collagen at arterial blood flow conditions. Arteriosder Hirottd) 14 1976-1983,1994. 

Model peptides that could build up quarternary fibrillar structures are not yet known. Though complete explanation of the interdependence between the primary structure and the stability of the quarternary structure has not yet been possible, i.e. the role of the different amino acids in collagen could be understood completely only in correlation with the fibril formation (formation of polar and hydrophobic clusters ). 

Gelatin (a denatured fibrillar protein collagen) is one of the most widespread natural high molecular mass surfactants in food, cosmetic, pharmaceutical, medicine, photographic industries as well as in the other fields. Addition of a low molecular mass component to gelatin provides the most effective influence on the surfactant properties. It is related to the formation of gelatin-surfactant complexes - a new type of surfactants. 

The formation of supramolecular assemblies of ECM biopolymers defines an obvious and highly important interconnection of physical and biospecific characteristics of the matrices. In general, multiple specific interactions between individual biopolymers, such as collagen or fibronectin, result in the formation of large fibrillar or meshwork-like structures segmenting tissues and guiding cells by microstructural features and mechanical characteristics. With those structures, often referred to as connective tissue, basement membrane, and several others, the unique functionality of ECM and the fact that it is based on both the provision of specific binding sites and physical forces is best represented. 

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