FGF-2 IN THE HEART

FGF-2 protein, lacking any classical hydrophobic export signal peptide, is secreted to the extracellular environment by a non-conventional, Golgi-independent path- 

The vast majority of work done to examine FGF-2 as a cardioprotective or angiogenic agent has focused on lo-FGF-2 acting at the cell surface. As more information is collected with respect to the specific actions of hi-FGF-2, as well as the mitogenic consequences of nuclear signaling, the relative importance of hi vs. lo-FGF-2 and cell surface vs. nuclear signaling in the context of cardioprotection will come to light. For now, we will focus on what is known about the acute and chronic effects of lo-FGF-2 in 

ELISSAVET KARDAMI, KAREN DETILLIEUX, SARAH JIMENEZ, PETER CATTINI 

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