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Fey receptor gene polymorphism

An understanding of Fey receptor gene polymorphism explains why some patients do not respond to monoclonal antibody, and it may broaden our understanding of monoclonal antibody activity and improve treatment outcomes in the future. Specific strategies include modulation of Fey receptor affinity or introduction of Fey receptor-reengineered monoclonal antibody designed to enhance binding to the Fey receptor. [Pg.205]

This chapter reviews our current understanding of the mechanism of action of monoclonal antibody (especially rituximab), as well as the role of Fey receptor and Fey receptor gene polymorphisms, and their impact on treatment outcomes in hematologic malignancies including follicular lymphoma (FL), diffuse large B-cell lymphoma (DL-BCL), Waldenstrom s macroglobulinemia (WM), and chronic lymphocytic leukemia (CLL). [Pg.205]

See other pages where Fey receptor gene polymorphism is mentioned: [Pg.204]    [Pg.219]    [Pg.204]    [Pg.219]    [Pg.205]    [Pg.217]    [Pg.208]    [Pg.219]    [Pg.79]   
See also in sourсe #XX -- [ Pg.205 , Pg.209 ]



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