Fever induction

Leukine GMCSF Eosinophil, SQ or IV or round to Low-grade fever induction chemotherapy in... 

E6. Egeberg, O., The effect of unspecified fever induction on the blood clotting system. 

The mechanism of fever induction has been studied most extensively. The brain is protected from the potentially harmful effects of biologically active substances or cells in the circulation by the blood-brain barrier, which is manifested by the extremely tight junctions between the endothelial cells lining blood capillaries,48 which prevent circulating substances of a particular size and chemical property (as well as cells) from entering the brain. Proinflammatory cytokines are of a sufficiently large size that makes it unlikely that they can pass the blood-brain barrier. However, numerous pathways to explain how cytokines produced in the periphery can influence central nervous system events have been studied. For example, highly localized... 

F23. Fontana, A., Weber, E., and Dayer, J. M. Synthesis of interleukin-l/endogenous pyrogen in the brain of endotoxin-treated mice A step in fever induction J. Immunol. 133, 1696-1698 (1984). 

Treatment with specific antibodies (ALG, ATG, anti-CD3, anti-CD25) is indicated during the induction phase after transplantation and in the case of acute rejection for short time periods. Therapy with nonhuman antibodies may cause sensitization. Muromonab-CD3 might initiate a cytokine release syndrome (fever, chills, headache). 

IL-6 (21-28) Monocyte/macrophage, T cell endothelium, fibroblast, keratinocyte Induction of fever and the hepatic acute phase response. Stimulates cortisol production. Decreases IL-1 and TNF production. Participates in activation of B and T cells, facilitates Ig production by B cells. Induction of granulocyte-macrophage colony-stimulating factor, stimulation of hematopoietic progenitors. 

Peripheral inflammation increases prostanoid levels at the site of inflammation and this contributes directly to inflammation and peripheral sensitization (prostanoids and inflammation are discussed in Ch. 33). Peripheral inflammation also increases central prostanoid levels as a result of the central induction of COX-2, to mediate widespread changes in pain sensitivity as well as fever, anorexia, altered mood and sleep patterns [19]. 

A 65-year-old man with acute leukemia recently underwent induction chemotherapy and subsequently developed neutropenia and fever (with no source of fever identihed). Fever persisted despite the use of empirical antibacterial therapy, and amphotericin B has been prescribed for possible fungal sepsis. Which laboratory test is LEAST helpful in monitoring for toxicities associated with amphotericin B ... 

Fludarabine Inhibits DNA synthesis and repair inhibits ribonucleotide reductase incorporation of fludarabine triphosphate into DNA induction of apoptosis Non-Hodgkin s lymphoma, CLL Myelosuppression, immunosuppression, fever, myalgias, arthralgias... 

Intramuscular methotrexate 50 mg/m2 followed by intravaginal misoprostol was effective in the induction of first trimester abortion. Adverse events following the administration of misoprostol included nausea (12%), vomiting (8.1%), diarrhea (7.4%), and fevers/chills (3.4%) (4). 

Proinflammatory cytokines, released by activated macrophages and monocytes during infection, can act on neural targets that control thermogenesis, behavior, and mood. In addition to induction of fever, cytokines induce other biological functions associated with the acute-phase response, including hypophagia and sleep. Cytokine production has been detected within the central nervous... 

Arsenic tri oxide 0.15 mg/kg/d IV for 60 days as induction therapy 0.15 mg/kg/d IV for 5 days per week for a total of 5 weeks as consolidation therapy Headache and lightheadedness Fatigue, cardiac dysrhythmias, fever, dyspnea, fluid retention and weight gain... 

EDTA is also used as a synergist to increase the activity of antioxidants, and to complex small amounts of heavy metal ions. EDTA has been frequently used to stabilize preparations of penicillins, ascorbic acid, epinephrine and prednisolone [4], Over the past 35 years, EDTA has been used to induce hypocalcaemia in cows and other species, primarily for the induction of hypocalcaemia as a model for milk fever [8]. 

Studies in animals clearly indicate that prostaglandins can produce fever when injected into the central nervous system and that Cox-2 induction is responsible for the fever that occurs with bacterial endotoxin and cytokines. To address the potential for an antipyretic effect in humans, Schwartz et al. (1999) administered rofecoxib or ibuprofen to young adults who presented to an infirmary for acute, nonbacterial... 

Aspirin is inducted into the Natural Museum of American History at the Smithsonian Institute for its century of reducing pains, aches, fevers, and inflammation, and for saving the lives of thousands of heart attack patients. 

Prostaglandins have been found to be involved in a number of important physiological functions, including the inflammatory response, the production of pain and fever, the regulation of blood pressure, the induction of blood clotting, and the induction of labor. 

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