Fever immunological mechanisms

Byssinosis is a bronchopathy due to inhalation of cotton dust, generally considered as an occupational asthma, although the immunological mechanism is still discussed. Respiratory syndrome induced by inhalation of nylon dust (Flock worker s lung) is considered different from HP (Kern et al. 2000). Metal fume fever following inhalation of metal fumes (zinc, copper) is an influenza-like reaction with poor respiratory symptoms different from HP. 

The underlying mechanism of a series of clinical entities associated with beta-lactams, such as maculopapular rash, drug fever, eosinophilia, serum sickness-like disease, vesicular and bullous skin reactions, erythema nodosum, and acute interstitial nephritis, is suspected to be immunological but is still largely unknown. 

Observational studies Yellow fever vaccine can very rarely cause severe adverse reactions, particularly neurotropic and visceral complications. Viral and host factors have been postulated to explain the basis of these reactions. However, the mechanisms underlying their occurrence remain unknown. A detailed immunological analysis of a 23-year-old woman has been published. She developed encephalitis, pancreatitis, and myositis after receiving a 17D-204 yellow fever vaccine and had various immunological abnormalities, which are described in detail in this chapter. The authors considered that the results supported the hypothesis that a strong adaptive response and abnormalities in the innate immune system may be involved in the establishment of severe adverse reactions after yellow fever vaccination [32 ]. 

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