Ferrocenyl derivatives

Chiral Pd catalysts can achieve enantioselectivity. The best catalysts developed to date are dimeric ferrocenyl derivatives.264... 

The crystal and molecular structure of the 44, 45, and C5-vinylferro-cenyl-thymidine show that the substituted cyclopentadienyl ring is essentially co-planar with the nucleobase (164). DFT calculations indicate that, irrespective of the extent of saturation in the bridging C2-unit in ethynyl-, vinyl- or ethyl-ferrocenyl-C5-thymidine, a similar amount of spin density is transferred to the nucleobase (Fig. 48). The reduction potentials for these compounds are shifted little compared to the parent ferrocenyl derivatives. 

For ferrocenyl derivative, the spectra analysis has revealed the presence of a Schiff base in the anti-(E) form in equilibrium with two of the diastereomers of oxazolidines generated by 5-endo-tring process in the... 

The application of organometallic complexes of the other group 8 elements, iron and osmium, in anticancer drug design has until recently been almost exclusively focused on iron, with the ferrocenyl derivative of tamoxifen (ferrocifen) being the most prominent example (104). Organometallic osmium compounds have been little explored in this respect. 

Benzylic acetates are unreactive toward organozinc compounds. However, various ferrocenyl acetates, such as 236, react with dialkylzinc halides in the presence of BF3 OEt2 with retention of configuration leading to the chiral ferrocenyl derivatives like 237 (Scheme 68) . 

SCHEME 68. Substitution with retention on ferrocenyl derivatives... 

Some —H - -Au contacts have also been described in gold complexes with ferrocenyl derivatives as ligands, such as those included in Table 5.2 containing... 

These lilhio derivatives are useful intermediates in the synthesis of various ferrocenyl derivatives. Some typical reactions are ... 

Very few calculations of cubic nonlinearities have been carried out. Table XV contains computationally derived static y values for ferrocene and some ferrocenyl derivatives. 

The Michael addition of (-)-dimenthyl malonate to a series of ,/i-imsaturated ketones, including ferrocenyl derivatives, has been reported to occur with 10—50% de pure diastereoisomers were obtained by recrystallization.83... 

Apart from these complexes, a number of heterodinuclear neutral compounds containing ferrocenyl derivatives as aryl ligands have also been prepared in recent years (see Table X). Most of them contain the ligand 2-(dimethylaminomethyl)ferrocenyl (FcN)104 106 and, with the sole exception of [(FcN)Au P(4-C1C6H4)3 ],106 have been... 

Heterodinuclear Neutral Complexes with Ferrocenyl Derivatives as Aryl Ligands... 

Other heterobimetallic aryl-phosphine-gold(I) complexes with different ferrocenyl derivatives, such as A-[2-A/,A/-(dimethylaminoethyl)-A-methyl-aminoethyl]-ferrocenyl (FcN,N), 2-nitroferrocenyl or ruthenocenyl, have also been reported. 

The use of ferrocenyl derivatives has also led to the synthesis of other trinuclear organogold(I) complexes that usually contain the fragment C-Au-P. Some of them contain l,l/-bis(diphenylphosphino)ferrocene (dppf) bridging two gold(I) atoms and a variety of aryl groups (see Table XV). They have been prepared by treatment of the trinuclear chloro derivative [(ClAu)2(dppf)] with two equivalents of the corresponding aryllithium [Eq. (39)] and their photophysical and electrochemical properties have been studied.126... 

Ferrocene has been used to replace functional groups, particularly phenyl rings, in existing chugs to give new compounds, but with mixed results. Some of these, such as the ferrocenyl derivatives of amphetamine and phenytoin, Chart 1, completely lacked the activity of the parent compounds [5]. Other ferrocenyl compounds, however, showed an improved therapeutic spectrum, such as the... 

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