Fenofibrate Cyclosporine

Drugs that may be affected by fenofibrate include anticoagulants, cyclosporine, and HMG-CoA reductase inhibitors. 

Fibric adds Clofibrate Gemfibrozil Fenofibrate Increase VLtt-catabolism PPAR , agonist LDLi 5-20% HDL t 10%-20% TG i 20%-S0% Gl upset, dyspepsia, gallstones, T LFTs, myopathy Nonmetabolism Warfarin Cyclosporine Statins Liver or severe renal disease primary biliary cirrhosis preexisting gallbladder disease... 

Clinically important, potentially hazardous interactions with allopurinol, amiodarone, amobarbital, anabolic steroids, anti-thyroid agents, aprobarbital, aspirin, barbiturates, bivalirudin, butabarbital, butalbital, cimetidine, clofibrate, clopidogrel, cyclosporine, delavirdine, disulfiram, fenofibrate, fluconazole, gemfibrozil, glutethimide, imatinib, itraconazole, ketoconazole, levothyroxine, liothyronine, mephobarbital, methimazole, metronidazole, miconazole, penicillins, pentobarbital, phenobarbital, phenylbutazones, piperacillin, prednisone, primidone, propylthiouracil, quinidine, quinine, rifabutin, rifampin, rifapentine, rofecoxib, salicylates, secobarbital, sulfinpyrazone, sulfonamides, testosterone, thyroid, zileuton... 

Clinically important, potentially hazardous interactions with cyclosporine, fenofibrate, gemfibrozil, HMG-CoA inhibitors (statins), ritonavir... 

Clinically important, potentially hazardous interactions with atazanavir, azithromycin, bosentan, cholestyramine, clarithromycin, cyclosporine, darunavir, delavirdine, erythromycin, exenatide, fenofibrate, fosamprenavir, gemfibrozil, grapefruit juice, imatinib, itraconazole, red rice yeast, tacrolimus, telithromycin, tipranavir, tolvaptan, verapamil... 

Other drags that suppress hver CYP2C11 and CYP3A2 levels include cyclosporine [203, 204] and chloramphenicol [205], although the latter effects are strain dependent and are associated with a modest reduction in plasma levels of thyroxine but not testosterone [205]. GH does not appear to play a role in the suppression of CYP2C11 and CYP3A2 by cyclosporine, which does not alter the plasma GH peak amplitude, niunber, or duration [206]. Phenobarbital [24, 207, 208], dexa-methasone [28], 5-fluoroiuacil [209], doxorubicin [210], fenofibrate [211], rosuvastatin [212],... 

Adefovir, amlodipine, busulfan, cefaclor, cefdinir, cefixime, citalopram, cyclosporine, fenofibric acid, hydrocodone, hydromorphone, lonafarnib, nalmefene, rosuvastatin voriconazole... 

SEDDS are particularly applicable for orally administered drugs, in soft or hard gelatin capsules that disintegrate in the gastrointestinal fluids (Sandri et al., 2010). Drugs with dissolution and bioavailability issues as fenofibrate (Soares et al., 2013), celecoxib (Fonte et al., 2011), or cyclosporine (Jin et al., 2011) have been formulated into SEDDS with success improvement of the oral controlled release of those drugs. 

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