Femoral artery thrombin injection

Thrombin-Induced Rabbit Femoral Artery Thrombosis Localized thrombosis can also be produced in rabbit peripheral blood vessels such as the femoral artery by injection of thrombin, calcium chloride, and fresh blood via a side branch (Shebuski et al. 1988). 

Fig. 6. Rabbit model of femoral arterial thrombosis. A clot is introduced into an isolated segment of femoral artery by injection of thrombin, CaCL, and whole blood. After aging for 1 h, t-PA is infused. Reperfusion is assessed by restoration of blood flow.

Recently, there has been in the use of other pharmacologic agents to modify the chronic total occlusion and render it more suitable for treatment (38-40). An animal model has been developed for testing these new approaches. In this rabbit model, thrombin is injected into an isolated portion of the femoral artery. After recovery, during the next two to four month, the thrombus is replaced by collagen which results in a chronic total occlusion. 

Fig. 6.4. Ultrasound of the groin, 90 days after thrombin injection reveals a small, residual hematoma (arrows), anterior to the femoral arteries...

Liau CS, Ho FM, Chen MF, Lee YT (1997) Treatment of iatrogenic femoral artery pseudoaneurysm with percutaneous thrombin injection. J Vase Surg 26 18-23... 

Taylor BS, Rhee RY, Muluk S, Trachtenberg J, Walters D, Steed DL, Makaroun MS (1999) Thrombin injection versus compression of femoral artery pseudoaneurysms. J Vase Surg 30 1052-1059... 

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