Fluid volume female

Mineral Oil Hydraulic Fluids. Absorption of a mineral oil in an emulsion was apparently very slow in female rats injected subcutaneously with 0.1 mL and in squirrel monkeys injected intramuscularly with 0.3 mL (Bollinger 1970). The emulsion contained 1 volume mannide monoleate, 9 volumes mineral oil, and 9 volumes water [14C]labeled hexadecane, a major component of the mineral oil, was added to the emulsion as a radiotracer. At 1 week and 10 months after treatment, radioactivity remaining at the sites of injection accounted for 85-99% and 25-33%, respectively, of the administered radioactivity. 

The adult male human body contains about 60% (weight) of water and the adult female body about 50%. The large amount of body water is compartmentalized, each compartment being bounded by membranes. It has been estimated (Edelman and Leibman, 1959) that 55% of this water is contained within cells and that it is bounded by cell membranes. The remaining, extracellular water or fluids (ECF) is made up of a relatively small volume of plasma (7.5% of total body water in the vascular tree), with the remaining 37.5% in nonplasma and located outside the vascular... 

Understanding Vd requires knowledge of the types of fluids into which a drug can distribute. A standard patient (70 kg, or 154 lbs) can be used to demonstrate key ideas. A 70-kg patient has approximately 5.0 L of blood. Because not every patient weighs 70 kg, blood volume is often expressed on a per mass basis as 0.071 L/kg (5 L/70 kg). Multiplication by patient mass gives that patient s approximate blood volume. Whole blood is 54% plasma by volume, so the amount of plasma in a 70-kg patient is 2.7 L. Other sources of fluid in the body include interstitial fluid and lymph ( 10 L) and intracellular fluids (—25 L). The total body water of a 70-kg male patient is approximately 38 L, or 55% of the body s mass. The value is closer to 50% for females. Total body volume for a 70-kg patient is around 70 L. 

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