Fatty add amide hydrolase

Mor, M., Rivara, S., Lodola, A., Plazzi, P. V., Tarzia, G., Duranti, A., Tontini, A., Piersanti, G., Kathuria, S., and Piomelli, D. (2004). Cyclohexylcarbamic acid 3 - or 4 -substituted biphenyl-3-yl esters as fatty add amide hydrolase inhibitors Synthesis, quantitative structure-activity relationships, and molecular modeling studies.. Med. Chem. 47, 4998—5008. 

Moreira, F. A., Kaiser, N., Monory, K., and Lutz, B. (2008). Reduced anxiety-like behaviour induced by genetic and pharmacological inhibition of the endocannabinoid-degrading enzyme fatty add amide hydrolase (FAAH) is mediated by CB1 receptors. Neuropharmacology 54, 141-150. 

Sagar, D. R., Kendall, D. A., and Chapman, V. (2008). Inhibition of fatty add amide hydrolase produces PPAR-alpha-mediated analgesia in a rat model of inflammatory pain. Br. J. Pharmacol. 155, 1297-1306. 

AA arachidonic acid, 2-AG 2-arachidonoyl glycerol, DHA docosahexaenoic add, FAAH fatty add amide hydrolase, DAGL sn-1-selective diacylglycerol lipase, MAGL monoacylglycerol lipase, NAPE-PLD N-acylphosphatidylethanolamine-selective phospholipase D... 

The fatty acid amides are destroyed by an integral membrane protein, a fatty add amide hydrolase. 21,322... 

This chapter discusses the current state of description of the genes encoding CBRs, from their serendipitous identification to the existence of an EPCS. This previously unknown but ubiquitous EPCS consists of the membrane cannabinoid receptors, their hgands, endocannabinoids that are known to act as retrograde messengers, and the associated proteins for their biosynthesis, e.g., phospholipase D, and for their inactivation, e.g., fatty add amide hydrolase (FAAH) and monoacylglycerols. 

Romero FA, Du W, Hwang I, Rayl TJ, Kimball FS, Leung D, Hoover HS, Apodaca RL, Breitenbucher JG, Cravatt BF, Boger DL (2007) Potent and selective a-ketoheterocycle-based inhibitors of the anandamide and oleamide cataboUzing enzyme, fatty add amide hydrolase. J Med Chem 50 1058-1068... 

Quistad, G.B., Sparks, S.E., Casida, J.E., 2001. Fatty add amide hydrolase inhibition by neurotoxic organophosphorus pestiddes. Toxicol. Appl. Pharmacol. 173, 48-55. 

Lichtman AH, Hawkins EG, Griffin G, Cravatt BF (2002) Pharmacological activity of fatty add amides is regulated, but not mediated, by fatty acid amide hydrolase in vivo. J Pharmacol Exp Ther 302(l) 73-9... 

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