Monoacylglycerol lipase

Monoacylglycerol lipase Long-chain acyl-CoA hydrolase... 

R. Mentlein, H. Rix-Matzen, E. Heymann, Subcellular Localization of Nonspecific Carboxylesterases, Acylcarnitine Hydrolase, Monoacylglycerol Lipase and Palmitoyl-CoA Hydrolase in Rat Liver , Biochim. Biophys. Acta 1988, 964, 319-328. 

Farooqui, A. A., Anderson, D. K., and Horrocks, L. A. (1994). Potentiation of diacylglycerol and monoacylglycerol lipase activities by glutamate and its analogs. J. Neurochem. 62, S74B... 

Unlike glutamate and NMDA, the treatment of neuron-enriched cultures with KA (100 /zM) has no effect on diacylglycerol and monoacylglycerol lipase activities (Farooqui et al., 1993 Farooqui and Horrocks, 1994). This suggests that... 

Fig. 5.4 Effects of glutamate on diacylglycerol lipase and monoacylglycerol lipase activities of neuron-enriched cultures from fetal mouse spinal cord. Diacylglycerol lipase (clear bars) and monoacylglycerol glycerol lipase (hatched bars). Data modified from Farooqui et al., 1993...

Fig. 5.10 Temporal changes in the monoacylglycerol lipase activity after ibotenate injection. Sodium chloride injected (clear bars) and ibotenate injected (hatched bar). Brains were removed after 1 day (1), 3 days (2), 10 days (3), and 6 months (4) after ibotenate injections. Monoacylglycerol lipase activity was determined in 10,000 rpm supernatant (having PM and SPM) fraction from hippocampal region. Data modified from Farooqui et al., 1991...

Farooqui A. A. and Horrocks L. A. (1997). Nitric oxide synthase inhibitors do not attenuate diacylglycerol or monoacylglycerol lipase activities in synaptoneurosomes. Neurochem. Res. 22 1265-1269. 

Fig. 2. Targeted lipidomics of 2-AG metabolism. Postulated pathways for 2-AG metabolism. Abbreviations PLC, phospholipase C DAG, diacylglycerol DGL, diacylglycerol lipase MGL, monoacylglycerol lipase PLA, phospholipase A AT, acyltransferase TAGL, triacylglycerol lipase PIP2, phosphatidylinositol bisphosphate ABHD-6/12 hydrolase lyso-PL, lysophospholipid lyso-PA, lysophosphatidic acid PA, phosphatidic add P, phosphatase COX, cydooxygen-ase LOX, lipoxygenase CYP450, cytochrome P450 CDP, cytidine diphosphate.

Dinh, T. R, Kathuria, S., and Piomelli, D. (2004). RNA interference suggests a primary role for monoacylglycerol lipase in the degradation of the endocannabinoid 2-arachidonoylglycerol. Mol. 

Hohmann AG (2007) Inhibitors of monoacylglycerol lipase as novel emalgesics. Br J Pharmacol 150 673-675... 

Quistad, G.B., Klintenberg, R., Caboni, P., Liang, S.N., Casida, J.E. (2006). Monoacylglycerol lipase inhibition by organophosphorus compounds leads to elevation of brain 2-arachidonoylglycerol and the associated hypomotilify in mice. Toxicol. Appl. Pharmacol. 211 78-83. 

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