Hydroxylated fatty acids

J. Schmitt, and R. D. Schmid, A continuous spectrophotometric assay for P450 BM-3, a fatty acid hydroxylating enzyme, and its mutant F87A, Anal Biochem. 1999, 269, 359-366. [Pg.307]

Plettner E., Slessor K. N. and Winston M. L. (1998) Biosynthesis of mandibular acids in honey bees (Apis mellifera) de novo synthesis, route of fatty acid hydroxylation and caste selective 8-oxidation. Insect Biochem. Molec. Biol. 28, 31-42. [Pg.15]

Boddupalli, S. S., Oster T., Estabrook, R. W., and Peterson, J. A. 1992b. Reconstitution of the Fatty-Acid Hydroxylation Function of Cytochrome-P-450bm-3 Utilizing Its Individual Recombinant Hemoprotein and Flavoprotein Domains. J. Biol. Chem., 267,10375-10380. [Pg.303]

Shah, J., Atienza, J. M Rawlings, A. V. and Shipley, G. G. (1995b). Physical properties of ceramides Effect of fatty acid hydroxylation. J. Lipid Res. 36 1945. [Pg.84]

P450BM-3 fatty acid-hydroxylating P450 from Bacillus magaterium... [Pg.1762]

Polysorbate 20 Polysorbate 40 Polysorbate 60 Polysorbate 80 Saponification value Polysorbate 20 Polysorbate 40 Polysorbate 60 Polysorbate 80 Composition of fatty acids Hydroxyl value Polysorbate 20 Polysorbate 40 Polysorbate 60 Polysorbate 80 Water... [Pg.582]

In 1957, we reported on the use of the detergent deoxycholate for the solubilization of aminoazo dye N-demethylase, and we also reported an inhibitory effect of CO on aminoazo dye N-demethylase activity (49). In a key study in 1968, Lu Coon described the deoxycholate-dependent solubilization and resolution of a liver microsomal fatty acid >-hydroxylation system into three components by column chromatography, and they were able to reconstitute catalytic activity by combining the three fractions (50). The three fractions were identified as cytochrome P450,... [Pg.10]

Low-density lipoprotein complexes (LDLs), which are the primary means of transporting cholesterol in the blood, are readily oxidized. These oxidations include peroxidation of unsaturated fatty acids, hydroxylation of cholesterol, and oxidation of amino acid residues in the apoprotein. A class of white blood cells recognizes the oxidation and absorbs the LDL through its scavenger receptor. After a white blood cell has absorbed numerous LDLs containing cholesterol, it becomes engorged and is referred to as a foam cell. Foam cells attract other white blood cells, which leads to accumulation of more cholesterol. Ultimately, this accumulation of cholesterol becomes one of the chief chemical constituents of the atherosclerotic plaque that forms at the site. [Pg.1847]

Include peroxidation of unsaturated fatty acids, hydroxylation of cholesterol, and oxidation of amino acids in apoprotein. [Pg.2423]

Lee, D.-S., A. Yamada, H. Sugimoto, I. Matsunaga, H. Ogura, K. Ichihara et al. (2003). Substrate recognition and molecular mechanism of fatty acid hydroxylation by cytochrome P450 from Bacillus subtilis. J. Biol. Chem. 278, 9761-9767. [Pg.113]

Finally, since fatty acid hydroxylations at the o), 00-1, 00-2, 00-3, and co-4 positions also occur in plants and bacteria °, acetylenic fatty acids have also been employed to examine whether these hydroxylases are mechanistically similar to their mammalian counterparts and/or to identify the role of specific plant and bacterial P450 enzymes °. Thus, midchain and terminal acetylenes such as 10-dodecynoic acid have been used as probes of plant lauric acid oo-hydroxylases . Similarly, 17-ODYA has been shown to inactivate P450g, 3 (CYP108), an enzyme that hydroxylates fatty acids at positions other than the terminal (oo) carbon, through a heme alkylation mechanism . [Pg.294]

Thiodipropionic acid antioxidant, fats/oils edible Dilauryl thiodipropionate antioxidant, fatty acids Hydroxyl amine Hydroxylamine sulfate antioxidant, fatty-based coating adjuvants paper/paperboard food-contact Di-t-butylhydroquinone antioxidant, fatty-based coating adjuvants paper/paperboard, aq./fatty/dry food-contact Diphenylamine... [Pg.4837]

Niestroj, A. Pyka, A. Sliwiok, J. The use of topological indexes to predict the Rm values of higher fatty acids, hydroxyl fatty acids, and their esters in RPTLC. J. Planar Chromatogr. Mod. TLC 2002, 15 (3), 177-182. [Pg.2349]

Lee DS, Yamada A, Sugimoto H, Matsunaga 1, Ogura H, Ichihara K, Adachi S, Park SY, Shiro Y (2003) Substrate recognition and molecular mechanism of fatty acid hydroxylation by cytochrome P450 imm Bacillus subtilis. Crystallographie, speetroseopie, and mutational studies. J Biol Chem 278 9761-9767... [Pg.27]

CYP505 CO-1 to CO-3 fatty acid hydroxylations (P450foxy) and fumonisin C14 and CIS hydroxylations Fatty acid degradation and fumonisin biosynthesis F. oxysporum and F. verticillioides [504, 693, 694] [840, 841]... [Pg.333]

Chun Y-J, Shimada T, Sanchez-Ponce R, Martin MV, Lei L, Zhao B, Kelly SL, Waterman MR, Lamb DC, Guengerich FP (2007) Electron transport pathway for a streptomyces cytochrome P450—cytochrome P450 105D5 catalyzed fatty acid hydroxylation in Streptomyces coelicolor A3(2). J Biol Chem 282 17486-17500... [Pg.396]

Kim KR, Oh DK (2013) Production of hydroxy fatty acids by microbial fatty acid-hydroxylation enzymes. Biotechnol Adv 31 1473-1485... [Pg.506]

Kaschnilz RM, Coon MJ (1975) Drug and fatty acid hydroxylation by solubilized human liver microsomal cytochrome P-450 phospholipid requirement. Biochem Pharmacol 24 295-297... [Pg.672]

Scheme 12.2 Fatty acid hydroxylation catalyzed by P450bm3 and camphor hydroxylation catalyzed by P450cam.

Shah J, Atienza JM, Rawlings AV, Shipley GG. Physical properties of ceramides effect of fatty acid hydroxyl-ation. / Lipid Res. 1995 36(9) 1945-1955. [Pg.105]

Wayne, L.L., Browse, J., 2013. Homologous electron transport components fail to increase fatty acid hydroxylation in transgenic Arabidopsis thaliana. FI000 Res. 2, 203. [Pg.272]

Synonyms Hydroxylated soybean oil fatty acids Soybean oil fatty acids, hydroxylated... [Pg.2160]

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