Fatty acids activities, comparative

Recently, Wongtangtintharn et al. (2004) showed that a series of iso- and animo-branched-chain fatty acids was cytotoxic to breast cancer cells. The highest activity was observed with iso-Ci o and the activity decreased as the chain-length increased or decreased from Ci6 o. Cytotoxicity of branched-chain fatty acids was comparable to that of RA and tram-10, a. v-12-C X 2. 

As can be seen from Table 1, the specific activity of long chain acyl CoA synthetase is significantly depressed in the Novikoff hepatoma and host liver when compared with normal liver. These results agree with those of Weinhouse et al. (1973) that made it clear that the activity of the fatty acid activating enzyme is very low in poorly differentiated hepatomas. There is no doubt that the growing tumor exerts a profound effect on the enzyme system of the host liver. On the other hand, no significant differences were observed in the activity of long chain acyl CoA thioesterase from the tissues under study. 

Nandanan et al. [35] reported the utilization of linseed oil as an MFA in nitrile rubber vulcanizates. Linseed oil not only acted as a plasticizer but also as the fatty acid component of the activator in the NBR vulcanizates. Use of linseed oil gave appreciable increase in properties like tensile strength, tear resistance, etc. while the viscosity of the compound was marginally lower than that of the control compound (which used di-octyl phthalate as the plasticizer). The vulcanizates containing linseed oil also exhibited increased cure rate as well as reduced leachability compared to the control at a dosage of 2-5 phr. This loading was seen to replace 6 phr DOP and 2 phr stearic acid in conventional NBR vulcanizates thereby reducing compound costs. 

In addition to p-oxidation, two other oxidation routes are known for fatty acids, referred to as a- and co-oxidation. However, they exhibit a lower activity and initially involve the formation of a- and o-hydroxy acids, with subsequent con-versions thereof. These oxidation routes are of inferior energetic value as compared with p-oxidation presumably, they are implicated in special functions of the cell. 

The long-chain, fatty acid esters of sucrose are non-ionic, nontoxic, and biodegradable, and compare well in overall performance with other surface-active compounds in detergency, emulsification, and... 

Enzyme-catalyzed transfer of KDO from CMP-KDO (127) into a lipid-A acceptor has been studied by Heath and coworkers,1 using a cell-free system from Escherichia coli O 111 J-5. LPS from the organism did not function as an acceptor, and only weak acceptor-activity was displayed147-148 by lipid A preparations obtained by mild, acid-catalyzed hydrolysis of LPS. Base-catalyzed, hydrolytic removal of the ester-linked, but not the amide-linked, fatty acid residues from lipid A resulted in an acceptor of maximal activity1 (see Scheme 38 compare Scheme 39). 

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