Fatty acid ethyl esters ethanol intake marker

Parts of this chapter are reprinted from Progress in Lipid Research, Vol 37, No 5,1998, pp. 307-316, M. Laposata, Fatty acid ethyl esters ethanol metabolites which mediate ethanol-induced organ damage and serve as markers of ethanol intake. Copyright (1998), with permission from Elsevier Science. 

Laposata M. Fatty acid ethyl esters ethanol metabolites which mediate ethanol-induced organ damage and serve as markers of ethanol intake. Prog Lipid Res 1998 37 307-316. 

FATTY ACID ETHYL ESTERS AS MARKERS OF ETHANOL INTAKE... 

Fatty acid ethyl esters may be clinically important, independent of whether FAEEs induce cytotoxicity, because they can serve as a marker for ethanol intake. We performed a study to determine the clinical utility of FAEE in the blood as a short-term confirmatory marker for ethanol intake and as a long-term marker for ethanol intake after ethanol is no longer detectable (Doyle, 1996), To isolate FAEEs from plasma for quantitation by gas chromatography-mass spectrometry (GC-MS) in these clinical studies, we developed a two-step method using solid-phase extraction with a recovery of 70 3%, using ethyl oleate as a recovery marker (Bernhardt, 1996). 

Doyle KM, Cluette-Brown JE, Dube DM, Bernhardt TG. Morse CR, Laposata M. Fatty acid ethyl esters in the blood as markers for ethanol intake. J Am Med Assoc 1996 276 1152-1156. 

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