Fast drug release

The hydrophobic core of nanoparticles is mostly made of solid glassy polymers such as polycaprolactone, polylactide, and their random copolymers. Drags are physically trapped and dispersed in the core. Except for the initial burst release period, the drug release from the solid nanoparticle cores tends to be a slow diffusion-controlled process [126]. Thus, nanoparticles responding to the acidic environments of tumor intercellular fluid or intracellular acidic compartments have been developed for fast drug release. 

We proposed PDEA-PEG micelles as lysosomal-pH-responsive fast drug-release nanoparticles for cytoplasmic drug delivery, as illustrated in Fig. 10.17 [97]. PDEA is soluble at acidic pH but insoluble at neutral pH [167-169], Its block copolymer with PEG (PDEA-PEG) forms pH-responsive nanoparticles [168], Once... 

Retinol Retinoic acid drug and lipids inducing complex dissociation and fast drug release [84-86]... 

Actually, the triple-coated inkjet paper as substrate was mostly smooth and least porous. The double-coated offset paper exhibited similar properties, whereas the uncoated paper substrate showed different properties such as a very fast drug release. 

Silica (hydrophilic) Very fast drug release (up to five times faster as standard dosage form) Immediately acting drug dosage forms... 

Another group of composite nanofibers are decorated or exocomposite nanofibers which are particularly developed for biomedical and sensor applications. The nanoparticles are located at the surface of nanofibers, which can lead to ultra-fast drug release, but do not play reinforcing role. 

Fast Drug Release Using Rotational Motion of Magnetic 284 Gel Beads... 

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