Fast atom bombardment mass spectrometr applications

Lanne, B., Olsson, B. -M., Larson, T., Karlsson, K. -A. (1996). Fast atom bombardment mass spectrometric analysis of glycosphingolipids by direct desorption from thin layer chromatography plates application of the method to a receptor-active 8-sugar glycolipid. Eur. Mass Spectrom. 2 361—368. 

In conclusion, I hope that I have shown that fast-atom bombardment mass spectrometry is a potentially useful tool for the synthetic chemist working in many areas of inorganic, organometallic, and coordination chemistry. In addition, as further fundamental research is done in the field with these applications in mind, the technique should become as routine as IR or NMR. Combined with developments in high-resolution NMR of solids, FAB should provide particularly useful data on supported catalytic reactions. Certainly FAB and the other complementary mass spectrometric techniques, mentioned in less detail, constitute a major way of quickly characterizing new compounds. 

Ukena, T, Satake, M., Usami, M., Oshima, Y, Fujita, T, Naoki, H., and Yasumoto, T 2002. Structural confirmation of ostre-ocin-D by application of negative-ion fast-atom bombardment collision-induced dissociation tandem mass spectrometric methods. Rapid CommunMass Spectrom 16, 2387—2393. 

Several mass spectrometric techniques including fast atom bombardment (FAB), plasma desorption (PD), matrix-assisted laser desorption/ionization (MALDI), and electrospray (ES) mass spectrometry (MS) are presently available for the analysis of peptides and proteins (Roepstorff and Richter, 1992). Of these techniques, mainly PDMS has gained footing in protein laboratories because the instrumentation is relatively cheap and simple to operate and because, taking advantage of a nitrocellulose matrix, it is compatible with most procedures in protein chemistry (Cotter, 1988 Roepstorff, 1989). Provided that the proper care is taken in the sample preparation procedure most peptides and small proteins (up to 10 kDa) are on a routine basis amenable to analysis by PDMS. Molecular mass information can be obtained with an accuracy of 0.1% or better. Structural information can be gained by application of successive biochemical or chemical procedures to the sample. 

Recent advances in mass spectrometric instrumentation and methodology have been reviewed within the context of the structural analysis of carbohydrates. A review (16 refs, in Chinese) on the application of fast atom bombardment (FAB)-m.s. to the analysis of 0-glycosides has appeared. ... 

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