Fang Chi

Han-fang-chi. Alkaloids have been recorded for four samples of this... 

According to Read, the name han-fang-chi is applied in China and Japan to Menispermum dauricum (p. 350), Sinomenium aeutum (p. 268) or Siephania japonica (p. 361), while fang-chi is a native name for S. ietrandra in Formosa. 

Of the alkaloids of the han-fang-chi group of drugs (p. 350), Ohta states that kukoline is a strong reflex and spasm stimulant and finally causes paralysis and death. Raymond-Hamet states that it suppresses the hypotensive action of dihydroxyphenylethanolethylamine. 

Etoricoxib 102, a 2,3-bipyridine derivative, has been used as a nonopioid analgesic <2003EP0912518>. A bis-tetrahydroisoquinoline derivative, tetrandrine 103, has been used an analgesic and is present in the Chinese drug han-fang-chi . 

N ortier JL, Martinez MC, Schmeiser HH, Arlt VM, Bieler C A, Petein M, Depierreux MF, De Pauw L, Abramowicz D, Vereerstraeten P, Vanherweghem JL. Urothelial carcinoma associated with the use of a Chinese herb Aristolochia fang-chi). N Engl J Med 2000 342(23) 1686-92. 

A. I, isolated for the first time in 1851 from the roots of birthwort Aristolochia clematitis), is widely distributed in the Aristolochiaceae and also occurs together with other nitrophenanthrenecarboxylic acids such as A. C in the Chinese drug Fang-chi Asarum canadense). Also widely distributed are A. D and A. IV. Aristoloside is the /9-D-glucoside of A. D and is isolated from Aristolochia manshuriensis. 

Tetrandiine Up-regulation of Bax, Bak, and Back and down-regulation of Bcl-2 and Bcl-xl, release of cyt-c and activation of caspase-3 and -9. Human gastric cancer BGC-823 cells Alkaloid isolated from the dried root of Hang-Fang-Chi (Stephania tetrandm) with apoptotic action in vitro a nd in vivo [149,150] [149]... 

This work was supported in part by the Office of Naval Research and National Science Foundation. The author thanks R. Kohlman, J. Joo, Vladimir Prigodin, Fang-Chi Hsu, June Hyoung Park, and Nan-Rong Chiou for discussions. 

Alkaloid isolated from the Chinese drug Han-Fang-Chi. Cryst. from EtOH or Me CO. M.p. 237-8°. Ale. FeClg—> bluish-green col. [ ]P 265-r ill OHOI3. 

Alkaloid from the Chinese drug, mu-fang-chi. Isomeric with tetrandrine. Needles -f IHgO. M.p. 127°, anhyd. 152°. [a] + 290° in CHClj. Heat at 150° — tetrandrine. 

TCM is based on natural products, primarily (>80%) plants. In China, many medicinal plants are used as folk dmgs (Min Chien Yao) however, TCM also holds a predominant and respected position in medicine and single or, more commonly, multiple formulated herbs are prescribed by TCM doctors as Chinese Materia Medica or traditional dmgs (Chung Yao) (I). Chinese medical literature has recorded over 100,000 (I Fang Chi Chieh) different formulas, usually containing 4 to 12 individual herbs with different pharmacological actions. 

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