Familial breast cancer genes

Other examples of single-gene diseases with delayed age of onset include familial breast cancer, familial colon cancer, adult polycystic kidney disease, and hemochromatosis. 

Mutation detection — Genetic mutations leading to disease states such as familial breast cancer can be detected by arrays, provided that sufficient gene probe sequence content is available in order to make a statistically significant prognosis. 

Gene Expression Profiling of Familial Breast Cancer... 

Without regard to therapy, potentially valuable diagnostic tests are available for presymptomatic evaluation of risk of breast cancer due to predisposition from BRCA 1 or BRCA 2 and of colon cancer related to familial adenomatous polyposis (APC gene) or hereditary nonpolyposis mismatch repair genes (MSH 2). Genetic predisposition to Alzheimer disease associated with ApoE4 is neither sufficient nor necessary to lead to the clinical condition, and no definitive therapy is available. 

Bowgogk, a. M., Molecular cloning of BRCAl a gene for early onset familial breast and ovarian cancer. Breast Cancer Res Treat, 1993, 28(2), 121—35. 

Mar) Claire King, epidemiologist at UC-Berkeley. reported the discovery of the gene linked to breast cancer in families with a liigli degree of incidence before age 45. 

---