Breast cancer genes

In contrast, the Tay-Sachs disease test patented by the Department of Health and Human Services costs about 100 per test, and the screening test for two breast cancer genes patented by a biotechnology firm costs 2,400 per test (Krimsky, 1999). 

Bergamaschi A, Kim YH, Wang P et al. Distinct patterns of DNA copy number alteration are associated with different elinieopathological features and gene-expression subtypes of breast cancer. Genes... 

Jarvinen, T. A. H., Tanner, M., Barlund, M., Borg, A., Isola, J. 1999. Characterization of topoiso-merase 11 a gene amplification and deletion in breast cancer. Genes Chromos. Cancer 20 142-150. 

ELECTROCHEMICAL DETECTION OF THE HYBRIDIZATION OF DNA STRAND RELATED TO BRCA1 BREAST CANCER GENE USING A TWO STRANDS ASSAY FORMAT... 

The voltammogram shown in Fig. 53.2 demonstrates the efficacy of the genomagnetic assay using as target a DNA strand related to the BRCA1 breast cancer gene. 

King, M-C. (1992). Breast cancer genes how many, where and who are they Nature Genetics 2,89 90. 

Fmally, metastasis occurs with other chromosome losses. The clinical usefulness of detection of mutations in tumor suppressor genes lies not only in the diagnosis and prognosis of cancer, but also in the prediction of susceptibility when the mutation is carried in the germline, such as with the breast cancer genes BRCAl and BRCA2. 

Izatt I, Greenman L Hodgson S, Ellis D> Watts S, Scott G, et al. Identification of germline missense mutations and rare allelic variants in the ATM gene in early-onset breast cancer. Gene Chromosome Cane 1999 26 286-94. 

Somasundaram, K. 2002. Breast cancer gene 1 (BRCAl) role in cell cycle regulation and DNA repair—perhaps through transcription. J. Cell Biochem. 88 1084-1091. 

Kolata, G. (2002). Breast cancer Genes are tied to death rates. New York Times, December 19. Lachenbruch, P. A., and Mickey, M. R. (1968). Estimation of error rates in discriminant analysis. Technometrics, 10 1-11. 

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