Factors That Regulate Uptake of Glucose by Muscle

Factors That Regulate Uptake of Glucose by Muscle A. Mitochondrial Regulation of Glucose Uptake by Muscle 

The results of experiments to be described below appear to show that anoxia and cell poisons which inhibit respiratory chain phosphorylation stimulate uptake of glucose by muscle and that under suitable conditions respiration of fatty acids and ketone bodies can lead to inhibition of glucose uptake. Since fatty acids and ketone bodies are oxidized by mitochondria and since the effects of anoxia and of these cell poisons will be exerted principally on mitochondrial metabolism it seems reasonable to accept these findings as common evidence for a regulatory effect of mitochondrial metabolism on glucose uptake. It is recognized that this concept is provisional until such time as the mechanism of this regulation has been established. 

Effects of Anoxia and Inhibitors of Respiratory Chain Phosphorylation 

The kinetics of the effect of anoxia on membrane transport and phosphorylation of glucose in perfusexl hearts from normal and alloxan diabetic rats have been analyzed in detail by Morgan et al. (1961a,b). In hearts from normal or diabetic rats, anoxia decreased the apparent Km oi transport 

Effects of Respiration of Falty Adds, Ketone Bodies, and Other Substrates 

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