Factor ganglioside binding

Ellipsometry can follow the interactions between two types of biological macromolecules, the first of those two bound physically to the surface, the other acting from the solution. The binding of conconavalin A to adsorbed mannan 180) and of cholera toxin to adsorbed ganglioside t83) are examples. The adsorption of complement factors to an antibody-coated surface was monitored by ellipsometry and a modification of the same method was used for quantification of migration inhibition of human polymorphonuclear leucocytes 182). Interaction of proteins and cells with affinity ligands covalently coupled to silicon surfaces has been also studied 183). 

G5 BMP-12R Brachyury CBF membrane ganglioside related to pericytes identification receptor to bone morphogenetic protein isoform 12 transcription factor related to embryo mesoderm determination core-binding factor protein family involved in cell differentiation... 

Bovine AAV has been shown to depend on gangliosides for entry [203], and binding to a2-3-linked sialic acid has been reported for AAV type 5, whereas AAV4 appears to bind to 2-6-linked sialic acid [204]. It has also been suggested that sialic acid serves not just as an attachment factor but is also required for vims internalization [205]. On the whole, however, the role of sialic acid in the AAV infection process is still poorly understood. 

Bremer EG, Hakomori S, Bowen-Pope DF, Raines EW, Ross R Ganglioside-mediated modulation of cell growth, growth factor binding, and receptor phosphorylation. J. Biol. Chem. 1984 259 6818-6825. 

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