FACIT

Fach-werk, n. framework, bay-work lattice-work checker work, -wissenschaft, /. special branch of science, specialty, -wort, n. technical word or term, -worterbuch, n. technical dictionary, -zeitschxift, /. special periodical, technical journal, trade journal. Facit, n. sum, result, answer. 

Then happens the miracle of miracles, as sure as death, and yet as masterful as life, a thing more miraculous, because so sudden, so apart From the usual course of evolution. Natura non facit saltum—nature never makes a leap. True—therefore this miracle is a thing as tl were against nature. 

Transmembrane collagen Basement membrane Basement membrane zone FACIT-like XVI, XIX... 

Figure 7 Domain structure of FACIT/FACIT-Iike collagens. The domains are named from the C-terminus as NC1, COL1, NC2 domains. The structures of the C-terminal domains are relatively homologous but the rest of molecules are various among the molecules. The domain annotation is dependent on the reference. ...

Figure 14 Possible FACIT cystine knot conformations based on NMR data of type XIV collagen cystine knot-containing peptide.

Another successful example of exploiting FACIT cystine knot was made on type XII collagen. A minichain consisting of COLl and the N-terminal portion of the NCI domain has been successfully self-assemhled into a triple helical homotrimer stabilized by the cystine knot." ... 

Collagen fibrils contain a number of collagen gene products. These can be conveniently divided into two classes (a) fibril-forming collagens and (b) fibril-associated collagens with interrupted triple helices (FACIT... 

The difference between the outcome of the Swiss Heart Study and that of FACIT illustrates how difficult it is to explain the results in terms of the biological effects of vitamin therapy. The positive results of the Swiss Heart Study seem to confirm the classical homocysteine hypothesis, which holds that homocysteine is an important atherosclerotic determinant and that lowering of homocysteine with vitamin therapy might reduce the rates of cardiovascular events. However, it is more difficult to explain the results of FACIT by an adverse effect of low plasma homocysteine, and consequently, a less simplistic perspective on the methionine-homocysteine metabolism and the multiple effects of folate, B6, and B 2 is needed. 

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