FACIT collagens

Shaw, L. M., and B. R. Olsen. 1991. FACIT collagens diverse molecular bridges in extracellular matrices. Trends Biochem. Sci. 16(5) 191-194. 

A second class of non-fibrillar collagens includes type IV molecules that form antiparallel sheet-like structures that make-up basement membranes. The third major class is the fibril associated collagens (FACIT) with interrupted triple helices including types IX, XII, XI and XVl. The FACIT collagens are separated into multiple domains of variable lengths. 

Transmembrane collagen Basement membrane Basement membrane zone FACIT-like XVI, XIX... 

Figure 7 Domain structure of FACIT/FACIT-Iike collagens. The domains are named from the C-terminus as NC1, COL1, NC2 domains. The structures of the C-terminal domains are relatively homologous but the rest of molecules are various among the molecules. The domain annotation is dependent on the reference. ...

Figure 14 Possible FACIT cystine knot conformations based on NMR data of type XIV collagen cystine knot-containing peptide.

Another successful example of exploiting FACIT cystine knot was made on type XII collagen. A minichain consisting of COLl and the N-terminal portion of the NCI domain has been successfully self-assemhled into a triple helical homotrimer stabilized by the cystine knot." ... 

Collagen fibrils contain a number of collagen gene products. These can be conveniently divided into two classes (a) fibril-forming collagens and (b) fibril-associated collagens with interrupted triple helices (FACIT... 

FACIT, fibril associated collagens with interrupted triple helices dc, discontinuous. 

FACIT Fibril-associated collagens COL9A1, COL9A2, [a1(IX)][a2(IX)][a3(IX)]... 

XII C0II2AI FACIT Interacts with types 1 and II collagen in soft tissues... 

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