Experimental termination date

Experimental termination date" means the last date on which data are collected directly from the study. 

Four time points have been defined in the OECD Principles for start and end of a study. The so-called study initiation and study completion dates do not contain any ambiguities that could give rise to interpretation difficulties. The dates when the Study Director signs study plan and final report are unambiguous calendar dates, and they clearly mark the two time points between which a study has been conducted. However, more difficulties are encountered with the experimental starting and completion dates for themselves and for their connection with initiation and termination dates. 

Another point to be made is connected with activities associated to the main study performance. The termination of the toxicokinetic part of a chronic toxicity or carcinogenicity study will obviously be delayed with respect to the experimental end of the in-life phase of the main study, if blood samples from the last treatment day are to be analysed. Should the study plan assign the end of the analytical determinations as the experimental end date, or should stiU the necropsy determine this date In analogy to the field studies, where analysis of the samples will constitute, scientifically speaking, the main... 

In addition to the posts)maptic receptors, dopamine autoreceptors also exist on the nerve terminals, dendrites and cell bodies. Experimental studies have shown that stimulation of the autoreceptors in the somatodendritic region of the neuron slows the firing rate of the dopaminergic neuron while stimulation of the autoreceptors on the nerve terminal inhibits both the release and the synthesis of the neurotransmitter. Structurally, the autoreceptor appears to be of the D2 type. While several experimental compounds have been developed that show a high affinity for the autoreceptors, to date there is no convincing evidence for their therapeutic efficacy. 

Shelf Life This term refers to the expected duration of the functional stability of biological substances, including immunochemicals, and most commonly is assessed by experimental tests, statistical work and observation. Within the user s laboratory, periodical comparisons of the working solution with aliquots kept frozen at -20 °C is recommended. The shelf life is terminated by an Expiration Date. 

This reaction is an important terminator in methane combustion but its main relevance for this work is as a test bed for theoretical models of unimolecular and recombination reactions. The most thorough experimental results to date (to be described below), covering the temperature and pressure ranges 296-604 K and 50-600 Torr, are still far from the high pressure limit even at the lowest temperature of the study. Whilst the experimental data can be extrapolated using phenomenological or RRKM procedures, Brouard et al. [66] used the isotopic reaction... 

For an accurate quantification of the content of substructures, it is essential that the NMR spectra are recorded under appropriate experimental conditions. In general, two effects can falsify the signal intensities (i) an incomplete spin-lattice (Ti) relaxation and (ii) a heteronuclear Overhauser effect, resulting from H decoupling. Typically, the NMR signal quantification is less crucial from the proton spectrum than from spectra of other nuclei, which require the correct choice of experimental conditions. To date, very few relaxation studies have been reported comparing data for terminal, linear, and dendritic units. Longer Tm values were... 

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