ExPaSy Web site

The importance of this information on biochemical reactions is emphasized by the fact that an image of the poster is also accessible on the ExPASy seiwer [20]. However, for this purpose, the poster has only been scanned. The ExPASy server provides a static image of the information on this web site, augmented only by links to additional information. 

The reactant is referred to as a substrate. Alternatively it may be a nutrient for the growth of cells or its main function may require being transformed into some desirable chemical. The cells select reactants that will be combined and molecules that may be decomposed by using enzymes. These are produced only by living organisms, and commercial enzymes are produced by bacteria. Enzymes operate under mild conditions of temperature and pH. A database of the various types of enzymes and functions can be assessed from the following web site http //www.expasy.ch/enzyme/. This site also provides information about enzymatic reactions. 

A number of Web sites offer services in the secondary structure predictions of proteins using different approaches with varied accuracy. The Secondary structure prediction of ExPASy Proteomic tools (http //www.expasy.ch/tools/) provides pointers to different Web servers for predicting secondary structures of proteins. The ProtScale of ExPASy Proteomic tools produces conformational profiles by plotting statistical scales of various parameters (e.g., Chou and Fasman s conformational propensities, Levitt s conformational parameters) against residue positions. 

Go to the SWISS-MODEL Web site (http //www.swissmodel. expasy.org), select Automated Mode, input the e-mail address and the amino acid sequence of the protein retrieved from the Protein Information table, and click Submit Modeling Request to build target protein structure. (See the crystal structure of SpoVT AbrB (pdb code 2W1T) for Bacillus subtilis in Fig. 1.)... 

The expasy server [33] offers references to many Web sites for protein sequence analysis and secondary structure prediction. 

The CMS Molecular Biology Resource [168] at the San Diego Supercomputer Center contains an excellent compendium of Web-accessible bioinformatics tools. The ExPASy (Expert Protein Analysis System] proteomics server of the Swiss Institute of Bioinformatics [169] and the EBI Toolbox are two other popular tool collections. Another useful resource is Herbert Mayer s Bioinformatics World Web site, which contains a comprehensive collection of bioinformatics tools and software, including evaluations, comments, and tutorials. 

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