Existing Studies and Literature Data

In practice there will often be old studies or published papers that can provide adequate information to assess the properties of phase in existing substances. The US Environmental Protection Agency (EPA) has issued useful guidance on searching for literature data (a. 15). 

It is important to evaluate existing studies with regard to their adequacy and completeness, especially where test standards vary. Guidance on evaluating data for use under the EU chemical schemes is given in the 

In vivo skin irritation (unless classified from Annex 

In vitro chromosome aberration test In vitro gene mutation assay Acute oral toxicity Acute inhalation or dermal toxicity 

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