Exertional heat stroke

Exertional heat stroke (EHS), a severe form of heat illness, occurs during exercise in the heat. Patients with the RyRl mutations associated with MH may be more susceptible to exertional heat stroke and, conversely, patients who have had EH episodes may be more susceptible to an MH response (Sei 1999 Wappler 2001 Davis and Pollock 2002). The two disorders appear to have many common features... 

Shieh, S.D., Lin, Y.F., Lin, S.H. Lu, K.C. 1995. A prospective study of calcium metabolism in exertional heat stroke with rhabdomyolysis and acute renal failure. Nephron, 71, 428-432. 

In 1910, Meyer-Betz reported the first published case of acute renal failure with muscular pain, weakness, and dark urine after intense exercise [5]. In 1960, Howenstine reported that this type of acute renal failure was exercise-related myoglobinuria [6], However, at this time, it was impossible to distinguish hemoglobin from myoglobin, and this type of acute renal failure was considered to be a type of heat stroke. However, in 1970, Jackson [7] reported that this disorder was exercise-related renal failure and muscle damage, and this publication led to a gradual increase in research interest in myoglobinuric acute renal failure. In 1972, Hamilton et al. [8] and Knochel [9], respectively, reported that similar cases were exertional rhabdomyolysis. Matsumoto et al.[10] first reported this disorder in Japan in 1976. 

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