Examples execution knowledge

RuleMaker the knowledge acquisition system induces decision trees from examples of expert decision-making, and expresses these decisions trees as executable Radial code. 

Remember that hazard is the potential of a substance to do harm -and it is a property of the substance that is ascribed to it by a regulatory body (in the UK usually the Health and Safety Executive). Hazard does not vary with the quantity of the substance, 1 mg has the same hazard rating as 1 kg - but risk to health does vary with the quantity. However, in the light of later experience and newly acquired knowledge, the hazard ascribed to a substance may be re-assessed from time to time. For example, both benzene and phenol are considered to be much more hazardous these days than they were 20 years ago, so make sure that the hazard data that you use are up to date. 

The necessity of the project must be evaluated. This can only be done after review of all documents, the study plan, and current data, and discussion with the current development leaders for the agent. It may be that sufficient knowledge has already been created for the project to proceed. It is important to address the trade-offs of doing versus not doing the simulation project. If, for example, a Phase 2 study has already documented efficacy, the dosing strategy, optimal patient selection for Phase 3, and Phase 3 would then be executed as a formality and for assessment of adverse events. In that case a modeling and simulation may not be necessary. 

A stub involves a set of code which produces known results. For example, a stub imbedded in ES code could contain "canned" facts rather than executable rules. A stub could be written to determine whether the output from a module is correct. The stub may be as simple as a "canned" temperature value as part of a rule. If the rule path is executing properly, that "canned" temperature value would be returned to the module. Stubs are usually utilized early in the ES software development cycle where linking rules, objects or frames are not available, but pieces or units of ES code are available. Stubs are also occasionally inserted in the integration phase to force a known result or to verify a portion of the knowledge-base. 

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