Dosing strategy

Donepezil is approved for the treatment of mild to moderate dementia of the Alzheimer s type at a dose of 5 mg/day. This dose should be increased to 10 mg/day if needed after 4 to 6 weeks. Table 32-5 describes the dosing strategies for all of the approved agents for Alzheimer s disease.34-38... 

Even in the case of an ideal dosing strategy, ammonia slip cannot be excluded if the SCR catalyst is cold, undersized, deactivated or if load jumps are large and very fast. As a consequence, the addition of an oxidation catalyst downstream of the SCR catalyst has... 

Figure 9.16. Effect of varying dosing strategies on the ammonia and HNCO slip during a load increase from 25 to 75 kW, which corresponds to a temperature increase from 230 to 400°C.

For children receiving chemotherapy of high or moderate risk, a corticosteroid plus SSRI should be administered. The best doses or dosing strategy has not been determined. 

The type of fatty acid employed may be a critical factor in the efficacy (or lack thereof). Omega-6 supplementation may have less impact than omega-3 administration (Hodge et ah, 1998). Typical dosing strategies are similar for both children and adults, namely from 3 to 10 g of refrigerated fish oil or 3 tablespoons of refrigerated flax seed oil per day, split into multiple administration times (e.g. three times per day). 

Ereshefsky L, Toney G, Saklad SR, et al A loading-dose strategy for converting from oral to depot haloperidol. Hosp Community Psychiatry 44 1155-1161, 1993... 

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