Example crystallization anti-solvent

In Tables 9.9-3 to 9.9-5 a summary of the recrystallization process of pharmaceuticals and bio-polymers, and co-precipitation by supercritical anti-solvent is presented. In Figures 9.9-1 and 9.9-2 examples of very long needle crystal and nano-particles are reported. 

Similarly, irradiation in the solid state of a 1 1 inclusion complex of coumarin with 241a led to the cis-anti-cis head-to-head dimer 244 as an almost pure enantiomer [187]. The selectivity observed was very sensitive to the nature of the solvent used for crystallization. Replacing a mixture of ethylacetate-hexane with toluene-hexane led to a different 1 1 complex and different photodimers. Furthermore, among the numerous inclusion complexes tested, only the preceding example using 241a as the host led to an enantioselective photodimerization of coumarin. 

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