Exaggerated pharmacology

Biology related includes target-disease linkage, clinical efficacy, and target-based toxicity (exaggerated pharmacology)... 

Key words Maternal toxicity, Embryo fetal development, Teratology, Exaggerated pharmacology,... 

Exaggerated pharmacological effects of diuretics to decrease sodium and water retention can result in complications relating to ion changes important in congestive heart failure. Possible adverse effects include the following ... 

Could have different pharmacological activity and/or feedback control (toxicity profile may be different if based on exaggerated pharmacology)... 

Toxicological Effects and Pharmacological Action In some cases only exaggerated pharmacological effects may be observed in the toxicological studies of the biopharmaceuticals. Sometimes these effects are difficult to distinguish from a compound-related toxicity. However, if the effect is related to the mechanism (predictable) and is reversible, it should not be considered as an adverse effect. 

Since toxicity usually arises from exaggerated pharmacological effects, sometimes combined with a narrow therapeutic range and/or a steep dose-response relationship from the NOAEL to toxicity, the pharmacologically active dose is often a more sensitive indicator of potential toxicity for biotechnology-derived pharmaceuticals (compared to the preclinical NOAEL adjusted by a safety... 

One of the most striking observations that can be made of the peptides as a class is their remarkable safety profile. Of all of the peptides currently on the market that were investigated for this analysis (Table 22.1), there was only one observation in the chronic toxicology studies that was not linked to exaggerated pharmacology. Admittedly, our analysis is biased by the fact that only approved compounds were included however, this data set is still very instructive. The observation in question was from enfuvirtide, a 36 amino acid linear peptide derived from the HIV-1 glycoprotein gp41 [15,16],... 

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