Evolution combinatorial chemistry

Woodyer, R., van der Donk, W.A. and Zhao, H.M. (2006) Optimizing a biocatalyst for improved NAD(P)H regeneration directed evolution of phosphite dehydrogenase. Combinatorial Chemistry High Throughput Screening, 9, 237-245. 

Klekota, B. Miller, B. L. Selection of DNA-binding compounds via multistage molecular evolution. Tetrahedron 1999, 55, 11687 (Combinatorial Chemistry Symposium in Print). 

A significant number of reviews and books on combinatorial libraries [1 1], molecular diversity [5-8], and solid-phase synthesis [9,10] have appeared in the last 3 years. For a more in-depth look at the evolution of this area, the reader is referred to these publications. In addition, a new journal has been started dealing with molecular diversity. This journal, Molecular Diversity, is published by ESCOM and is available in printed and electronic form. Associated with it is an Internet worldwide web site devoted to combinatorial chemistry and molecular diversity which can be accessed as www.vesta.pd.com. 

The experimental discipline that is now known as combinatorial chemistry—although it is also known by such evocative terms as test tube or in-vitro evolution—arose almost 30 years ago. At that time, RNA evolution experiments showed that it was possible to create selection-pressure conditions in an experimental setting that caused certain species of RNA, but not others, to survive from one generation to the next [2], This work was complemented by advances of theories on how biopolymers organize themselves and change over time under specific conditions [3]. About 13 years ago, the use of evolution and Darwinian selection was proposed for RNA [4] and for proteins [5] in an... 

Keywords Chemical evolution Dynamic combinatorial chemistry Self-replication Systems chemistry... 

Metz G, Ottleben H, Vetter D. Small molecule screening on chemical microarrays. Meth. Princ. Med. Chem. 2003 19 213-236. Ladame S. Dynamic combinatorial chemistry on the road to fulfilling the promise. Org. Biomol. Chem. 2008 6 219-226. Hioki H, Still WC. Chemical evolution a model System that selects and amplifies a receptor for the tripeptide D-Pro-L-Val-D-Val. J. Org. Chem. 1998 63 904-905. 

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