Eudragit-coated capsules

FIGURE 2.5 Hypoglycemic effect of insulin administered orally to normal rats by means of coated soft capsules containing an absorption-enhancing formulation (8 IU porcine insulin, 4 mg sodium laurate (Ci2) and 16 mg cetyl alcohol) two capsules RSI (open stars) 2 capsules RS2 (open circles) 2 capsules RS2 + 1 capsule surfactant post-insulin administration (open square) insulin i.p. 4 IU (close circles) 2 placebo capsules (no insulin) (close stars). Each point is the mean SD of five animals for insulin administration and of four animals for controls. RSI and RS2 are capsules coated with various mixtures of Eudragits RS, S, and L. (From Touitou, E. and Rubinstein, A., Int. J. Pharm., 30, 95, 1986. With permission from Elsevier.)... 

Fig. 11 Force-deflection profiles of soft gelatin capsules containing polyethylene glycol as a fill liquid and coated with Eudragit L 30 D-55 obtained from compression testing (A) polymer plasticized with 20% triethyl citrate (B) polymer plasticized with 20% tributyl citrate. (From Ref. l)...

J. W. McGinity, Physical and enteric properties of soft gelatin capsules coated with Eudragit L30 D-55, Int J Pharm 773 17-24 (1995). 

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