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Eudesmanolide sesquiterpene

Eudesmanolide sesquiterpene lactones (G6 G6 C40L) include a variety of variously cytotoxic compounds. The antifeedants alantolactone and isoalantolactone (helenin being a mixture of the two) (C6 ] C5 C40L=CH2) are antimicrobial. The pro-apoptotic activity of these compounds may derive from the reactivity of the a-methylene-y-butyrolactone ring... [Pg.37]

Frullanolide (eudesmanolide sesquiterpene lactone) 18(3-Glycyrrhetinic acid... [Pg.324]

Alantolactone (eudesmanolide sesquiterpene lactone) Inula helenium I. spp. (Asteraceae) Insect antifeedant... [Pg.443]

Eudesmanolides. Sesquiterpene lactones with the eudesmane basic skeleton mainly from Asteraceae. On the basis of the ring closure of the y-lactone group two forms are distinguished the santanolides in which the lactone oxygen is linked to carbon atom 6 (e.g., santonin, artemisin) and the alantolides (e.g., helenin ) in which linkage occurs at carbon atom 8. Lit. Beilstein EV 17/10, 97 Tetrahedron 33, 617 (1977). gen. Planta Med. 14, Suppl., 97 (1966). [Pg.220]

The allergen eudesmanolide sesquiterpene lactone was isolated from elecampane (Inula helenium L.). With dehydrocostuslactone and costunolide, it is a component of the (sesquiterpene) lactone-mix, used to detect sensitization to Compositae. [Pg.1126]

In summary, feverfew appears to be a source of a range of sesquiterpene lactones of three different types germacranolides, eudesmanolides and guaianolides. [Pg.225]

The new eudesmanolide, ip,4a,6a-trihydroxyeudesm-ll-en-8a-12-olide (26) and the guaianolides pyrethroidinin (162) and parishin A (159) were isolated from T. densum ssp. amani together with the known sesquiterpene lactones, deacetyllaurenobiolide (81), parthenolide (87), tanachin (103), 8-deoxycumambrin B (141), peroxyparthenolide (91), dentatin A (14), 8a-hydroxyanhydroverlotorin (119), spiciformin (97),... [Pg.596]

Synthesis of 6,12-sesquiterpenolides This section describes the synthesis of sesquiterpenes bearing a lactone moiety between C(6) and C(12). The transformation of the A-ring in santonin to give eudesmanolides, guaianolides, and elemanolides, as well as the modification of the lactone ring is described. Some microbiological transformations of santonin and its derivatives are also described. [Pg.53]

Costunolide (165), a very unstable sesquiterpene y-lactone, from Saussurea radix, was treated in Aspergillus niger to produce three dihydrocostunolides (166-168) (Clark and Hufford, 1979). Costunolide is easily converted into eudesmanolides (169-172) in diluted acid, thus 166-168 might be biotransformed after being cyclized in the medium including the microorganisms. If the crude... [Pg.767]

The genus Lactuca (L. perennis, L. tatarica, L. indica, L. capensis, L. tenerrima) has been shown to produce sesquiterpene lactones including guaianolides, germacranolides, and some eudesmanolides. Two new eudesmane sesquiterpene lactones show anticancer activity against epithelial carcinoma and colon carcinoma cell lines [77]. [Pg.3530]

Danaei G, Vander HS, Lopez AD, Murray CJ, Ezzati M (2005) Causes of cancer in the world comparative risk assessment of nine behavioural and environmental risk factors. Lancet 366 1784 Boik J (2001) Natural compounds in cancer therapy, printed in USA, p 1 Hansel R, Kartarahardja M, Huang JT, Bohlmann E (1980) Sesquiterpen lacton-d-glucopyranoside sowie ein neues Eudesmanolid aus Taraxacum officinale. Phytochemistry 19 857... [Pg.3544]

Bohlmann F, Zdero C, Jakupovic J, Robinson H, King R M 1981 Eriolanolides, eudesmanolides and a rearranged sesquiterpene from Eriphyllum species. Phytochemistry 20 2239-2244... [Pg.794]

In North America and Europe, it has long been known that some occupational allergies are associated with handling of wood on which epiphitic liverworts grow. The hapten of this allergy is a sesquiterpene lactone, (—)-frullanolide (338), isolated from Frullania tamarisci ssp. tamarisci, or ( + )-frullanolide (339) from F. dilatata 14,18, 30, 32,37,175, 255, 287). The isolation of these compounds represented the first discovery in bryophytes of compounds with biological activity in humans. The eudesmanolides (349) and (352) and the eremophilanolide (322) also caused intense allergies. Patients sensitive to Frullania species are all sensitive to at least one of the lactones isolated from F. dilatata 30). [Pg.187]

Ohta, Y., N. H. Andersen, and C.-B. Liu Sesquiterpene Constituents of Two Liverworts of Genus Diplophyllum. Novel Eudesmanolides and Cytotoxicity Studies for Enantiomeric Methylene Lactones. Tetrahedron 33, 617 (1977). [Pg.282]

Lin, Y.-C., Abd El-Razek, M.H., and Shen, Y.-C. (2010a) Vertirillane-type diterpenoids and an eudesmanolide-type sesquiterpene from the Formosan soft coral Cespiudaria kypotentaculata. Hdv. Chim. Acta, 93, 281-289. Erratum Hdv. Chim. Acta, 93,1238-1239 (2010). [Pg.1386]

See other pages where Eudesmanolide sesquiterpene is mentioned: [Pg.211]    [Pg.269]    [Pg.447]    [Pg.63]    [Pg.211]    [Pg.269]    [Pg.447]    [Pg.63]    [Pg.98]    [Pg.888]    [Pg.888]    [Pg.293]    [Pg.293]    [Pg.435]    [Pg.450]    [Pg.595]    [Pg.635]    [Pg.638]    [Pg.478]    [Pg.481]    [Pg.482]    [Pg.312]    [Pg.924]    [Pg.660]    [Pg.595]    [Pg.635]    [Pg.638]    [Pg.72]    [Pg.392]    [Pg.937]    [Pg.2676]    [Pg.3528]    [Pg.78]    [Pg.725]    [Pg.55]    [Pg.193]    [Pg.289]   
See also in sourсe #XX -- [ Pg.37 ]



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