2-Ethylamino- -Hydrochlorid

Indan 2-Ethylamino- -Hydrochlorid E16d, 924 (reduktive Atninierung) Indol l-Ethyl-2-methyl-2,3-dihydro-E19b, 876 (Carben-C,H-Inser-tion)... 

Ethylamino- -Hydrochlorid 910 2-(4-F uor-ani ino)- -Hydrochlorid 910 2-Methylamino- -Hydrochlorid aus 3-Amino-2-chlor-pyridin und Methyl-isothiocyanat 910... 

The resulting solution was filtered through animal charcoal and, after addition of 2 liters of methanol, it was debenzylated by hydrogenation at 60°C over palladinized charcoal as a catalyst. After removal of the catalyst by filtration, the filtrate was concentrated by evaporation, whereupon the hydrochloride of 1-p-methoxyphenyl-2-((3-3, 5 -dihydroxyphenyl-(3-oxo)-ethylamino-propane (MP 244°C) crystaiiized out. For the purpose of demethyiation. 

The collected ethereal filtrates were acidified with 50 ml of 4 N hydrochloric acid and tills solution was stirred vigorously. The hydrochloride of 1-(4 -benzyloxyphenyl)-2-(1 -methyl-2-phenoxy-ethylamino)propanone-1 precipitated out, was filtered off, washed with water and then with diethyl ether. Then this substance was dried in vacuo. The yield was 37.7 g, i.e., 89% of the theoretically possible yield, calculated on 1-(4 -benzyloxyphenyl)-2-bromine propanone-1. This substance had a light yellow color and melted at 197° to 198°C, while decomposing. 

D) 4 -[N-Ethyi-1 "-Methyl-2 -(4" -Methoxyphenyl)Ethylamino]Butyi-3,4-Dimethoxybenzoate Hydrochloride 10.3 g of 4 -iodobutyl-3,4-dimethoxybenzoate and 11.0 g of N-ethyl-p-methoxyphenylisopropylamine (obtained by catalytic reduction of an alcoholic solution of an excess quantity (60%) of p-methoxy-phenyl-acetone, to which was added a 33% (weight-for-weight) aqueous solution of ethylamine, with Pt as a catalyst), were boiled in 200 ml of methyl ethyl ketone for 20 hours, cooled and the iodine ion was determined the reaction was found to be complete. Then the methyl ethyl ketone was evaporated in vacuo and the residue was dissolved in 300 ml of water and 30 ml of ether the layers were separated and the water layer was extracted twice more with 20 ml portions of ether. 

A solution of 44 grams of 2-bromo-4 -benzyloxypropiophenone and 44 grams of 2-(4-meth-oxyphenyDethylamine in 270 ml of ethanol was refluxed for 3 hours. Then the ethanol was distilled off in vacuo and the concentrate mixed with ether. The resulting crystallizate was Sucked off after which the filtrate was mixed with an excess of 2 N hydrochloric acid. As a result of this the hydrochloride of 4 -benzyloxy-2-[2-(4-methoxyphenyl)ethylamino]-propiophenone slowly crystallized. This substance was also Sucked off, washed with water and alcohol, and dried in vacuo. After recrystallization from dilute alcohol the yield was 25.5 grams of a product with a melting point of 217 to 218°C. 

The heating of [2-(3,4-dimethoxyphenyl)ethylamino]methylenemal-onates (1386) in 24% aqueous hydrochloric acid gave tetrahydroisoquino-line-l-acetic acid hydrochlorides (1387) in good yields (56JOC336 761JC784). 

Introduction of the C2 sulfonamide is accomplished via sulfonylation with chlorosulfonic acid, conversion to the sulfonyl chloride using thionyl chloride, and amidation using concentrated ammonium hydroxide in tetrahydrofuran. Reduction of the 4-acetamido compound using borane-tetrahydrofuran complex provides the 4-ethylamino derivative. The 45,65-frans diastereomer is selectively crystallized as its maleate salt from acetone in the presence of the unwanted 4R,6S-cis diastereomer. Neutralization of the maleate salt and extraction of the free base in ethyl acetate, followed by formation of the hydrochloride salt, yields crude dorzolamide hydrochloride. 

Chlor-2-( ethylamino-imino-methylamino)-benzimidazol-bis-[Hydrochlorid] 20% Schmp. 192-194° (Zers.)... 

Wenn man bei der vorstehend beschriebenen Reaktion 2-Methyl-1-oxo-cyclohexan reduk-tiv z.B. mit (R)-1 -Phenyl-ethylamin aminiert, erhalt man (1 R,2S,aR)-2-Methyl-1 -(1 -phe-nyl-ethylamino)-cyclohexan (als Hydrochlorid 88%), das durch Hydrierung iiber Palla-dium/Kohle zu (17 ,2S)-1 - Amino-2-methyl-cyclohexan (als Hydrochlorid 78% 96% ee) und Ethylbenzol gespalten werden kann2. 

N-Ethyl-N-(l,3,4-thiadiazol-2-yl)amidophosphoryl chloride is prepared by refluxing 16.4 parts of 2-ethylamino-l,3,4-thiadiazole hydrochloride with 84 parts of phosphorus oxychloride for 6 h and then removing the excess phosphorus oxychloride by distillation under reduced pressure. The residual oil is washed with cold petroleum ether, dried and dissolved in 310 parts of dry benzene. 

D) 4 -[N-Ethyl-l"-Methyl-2"-(4" -Methoxyphenyl)Ethylamino]Butyl-3,4-Dimethoxybenzoate Hydrochloride 10.3 g of 4 -iodobutyl-3,4-dimethoxybenzoate and 11.0 g of N-ethyl-p-methoxyphenylisopropylamine (obtained by catalytic reduction of an alcoholic solution of an excess quantity (60%) of p-methoxy-phenyl-acetone, to which was added a 33% (weight-for-... 

The resulting residue, which consisted of the hydrochloride of 4 -hydroxy-2-[2-(4-methoxyphenyl)ethylamino]propiophenone, was mixed with 30 ml of a 48% hydrobromic acid solution and the mixture was boiled until no methylbromide developed any more, which was the case after approximately... 

Ethoxyphenoxy)ethylamino]-l-hydroxy-2-methylethyl -2-methoxybenzenesulfonamide hydrochloride Thionyl chloride Palladium on carbon Hydrogen... 

In 1,000 ml of acetonitrile was suspended 17 g of 5- 2-[2-(2-ethoxyphenoxy)ethylamino]- 1-hydroxy- 2-methylethyl -2-methoxybenzenesulfonamide hydrochloride and while stirring the suspension,... 

In methanol was dissolved the 5- l-chloro-2-[2-(2-ethoxyphenoxy)ethylamino]ethyl -2-methoxybenzenesulfonamide hydrochloride and after adding thereto 10% palladium carbon, dechlorination was performed under hydrogen stream at normal temperature and pressure. The palladium carbon was filtered away and the filtrate was concentrated under reduced pressure to provide the 2-methoxy-5- 2-[2-(2-ethoxyphenoxy)ethylamino]ethyl>benzenesulfonamide hydrochloride, which was recrystallized from 120 ml of a mixture of methanol and ethanol (1 4 by volume ratio) to provide the colorless crystals thereof. The melting point of the 5- 2-[2-(2-ethoxyphenoxy)ethylamino]-2-methylethyl -2-methoxybenzenesulfonamide hydrochloride 254°-256°C. 

Hydrochlorid E2, 130 [(Benzyl-carboxymethyl-amino)-methyl]-tri-chlormethyl- E2, 129 Benzyl-ethyl- -ethylester XII/1, 257 [ -(l-benzylidenamino-ethylamino)-benzylJ-methyl-E2, 131... 

DNA600 CAS 13055-82-8 HR 3 7- 3- 2- 3,5-DIHYDROXYPHENYL-2-HYDROXY-ETHYLAMINO)PROPYL))-THEOPHYLLINE HYDROCHLORIDE... 

T. J. Blacklock, P. Sohar, J. W. Butcher, T. Lamanec, E. J. J. Grabowski, An enantioselective synthesis of the topically-active carbonic anhydrase inhibitor MK-0507 5,6-di-hydro-(S)-4-(ethylamino)-(S)-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide hydrochloride,/. Org. Chem. 1993, 58, 1672-1679. 

Synthesis of 14C-labelled 5-[1 -hydroxy-2-[2-(o-methoxyphenoxy)-ethylamino]ethyl]-2-methylbenzenesulphonamide hydrochloride (YM-09538)... 

Tripelennamine can be prepared as follows 2-aminopyridine, prepared by the action of sodamide on pyridine, is reacted with P-dimethylaminoethyl chloride in the presence of sodamide, and the resulting 2-[2-(dimethylamino) ethylamino] pyridine is subsequently condensed with benzyl bromide in the presence of sodamide. The corresponding hydrochloride salt is obtained from the base by treatment with hydrogen chloride in an organic solvent. 

N, N-Dimethyl-2[o-methyl-a-phenylbenzyl) oxy] ethylamino citrate (1 1) Ethanamine, N, N-dimethyl-2-[(2-methylphenyl) phenylmethoxy]-, 2-hydroxy-l, 2, 3-propanetricarboxylate (1 1) Mephenamine Hydrochloride Orphenadin Hydrochloride BP USP ... 

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