Ethyl solubility issues with

There is also the important issue of data consistency. Many drugs and excipients have had their pK values measured by different methods with very good agreement, provided that all experimental conditions were maintained constant. Examples included atenolol [9.60 0.04 potentiometric, partitioning, and capillary electrophoresis (CE) studies in different laboratories], barbital (5,5-diethylbar-bituric acid) (7.98 0.01 electrometric, potentiometric, and spectrophotometric studies in different laboratories), benzoic acid (4.205 0.015 electrometric, potentiometric, spectrophotometric, and conductance measurements in many separate studies), ephedrine (9.63 0.05 five potentiometric or spectrophotometric studies in different laboratories), isonicotinic acid (pKi = 1.77 0.07, pK2 = 4.90 0.06 five potentiometric or spectrophotometric studies in different laboratories), nicotinic acid (pfCi = 2.07 0.07, pK2 = 4.79 0.04 six potentiometric, spectrophotometric, or capillary zone electrophoresis studies in different laboratories), phenobarbital (5-ethyl-5-phenylbarbituric acid) (7.48 0.02 potentiometric and spectrophotometric studies from several workers in multiple laboratories), nime-sulide (6.51 0.05 potentiometric and spectrophotometric studies in multiple laboratories), and chlorthalidone (9.35, potentiometric 9.36, spectrophotometric/ solubility-pH). The recent comparative studies of Takacs-Novak, Avdeef, and... 

The role of solvents is to reduce the viscosity of adhesives and to improve fluidity. That can provide the adhesives wettability to create an intimate contact with the surface of adherends. Solvents must be able to dissolve the components of adhesives. Solubility parameter is an index to show the soliditivity of solvents. A solvent can dissolve a high amount of materials whose solubility parameters are close to that of the solvent. Water, alcohols, aromatic hydrocarbons (e.g., toluene and xylene), ketones (e.g., methyl ethyl ketone and cyclohexanone), acetate esters (e.g., ethyl acetate and butyl acetate), n-hexane, cyclohexane, methylene chloride are used due to their solubility, dehydration rate, noncombustibility, and workability. To meet the demands concerning environmental issues, the use of some solvents such as toluene, xylene, ethylbenzene, and styrene is restricted bylaws such as the air pollution control law legislated by Ministry of the Environment in Japan (The Ministry of the Environment 1996). 

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