Phenyl ethyl sulphone

With chloroacetyl chloride it gives the chloroacetic ester of chloromethyldicthylcarhinol, CH2Ci.C(C3H5)2.0.C0.CH2Cl with butyryl chloride it forms hexanom(3) with benzoyl chloride, ethyl phenyl ketone is obtained, and with benzene sulphonic chloride, the main product is zinc benzene sulphinate and a little sulphone. 

Retinol Derivatives. The sulphone method forms the basis of three new synthetic routes to vitamin A (retinol 95), involving condensation of the /3-ionylidene-ethyl (Cis) phenyl sulphone (96) with the epoxide (97) " or the chloride (98) or condensation of the /8-ionyl phenyl sulphone (99) with the allylic chloride (100). Conditions have been developed under which the elimination of the sulphone group from the reaction intermediate (101) occurs efficiently. In another stereospecific... 

Typical of this work is the rearrangement of phenyl p-toluenesulphonate into 2-hydroxyphenyl and 4-hydroxyphenyl p-tolyl sulphones274. Ogata and coworkers275 have shown that phenyl benzenesulphonate also rearranges on irradiation in ethanol and yields both 2-hydroxyphenyl and 4-hydroxyphenyl phenyl sulphones as well as phenol, small amounts of diphenyl ether and polymer. Interestingly, the tolyl derivative 305 does not rearrange and only o- and p-cresol are isolated. Irradiation (330 nm) of the sulphonates 306 in ethyl acetate affords the hydroxysulphones 307 in 66% yield. The reaction of 306 also... 

Homolysis of the S-acyl bond is responsible for formation of phenylthio-cyclohexane and 3-phenylthiocyclohexene from. SiS -diphenyl dithiocarbonate by irradiation in cyclohexene.117 A cyclic mechanism, however, has been proposed to account for the photodecomposition of certain carbohydrate dithiobisthio-formates.118 On irradiation, 0-ethyl thioacetate is converted into cis- and / 5-2,3-diethoxybut-2-ene, together with small amounts of 2,3-diethoxybut-l-ene, 2,3-diethoxybuta-1,3-diene, and 1-ethoxyethane-l-thiol.119 121 Free sulphur was trapped by reaction with 1,2-dimethyIenecyclohexane. Details of the photoelimination of sulphur dioxide from D-glucofuranosyl phenyl sulphone acetates have been published.180 An efficient synthesis of another 1,8-bridged naphthalene... 

Deoxy-L-threose and -erythrose derivatives are available from ethyl 0-benzyl-L-lactate by chain elongation with the formyl anion eguivalent (21) and subseguent reduction of ketone (22) (Scheme 5). The anion of methyl phenyl sulphone has been added... 

Azo acid blue, azo cyanme, azo merino blue, azo navy blue, brilliant cloth blue, chromazone blue,dommgo blue black, eno fast brilliant blue, ethyl acid blue, cresol blue black, lanacyl blue, naphthol blue black, naphthylamme blue black, " orthocyanme, phenyl blue black, sulphon acid blue, tolyl blue S B, S R, S T... 

I. Sehottle on benzene sulphonate, by A. Seyewetz and L. Poizat on phenyl hydrazine, by E, Fischer on zinc ethyl and magnesium alkyl halides, by F. Ebler and R. L. Krause on metaphosphoric esters and phosphorous esters, by W. Streoker and H. Heuser etc. 

For example, addition of the anion of phenyl ethyl sulphone to benzyl trimethylsilyl ketone gives a silyl enol ether by the pathway depicted in Figure Si6.8. 

The reaction of enamines and imines with acrylamide results in aza-annulation120,121. Other electrophilic alkenes which have been used to alkylate enamines and the products used in hetero- or carbocyclic synthesis include ethyl / -nitroacrylate122, where reaction occurs beta to the nitro not the ester group, 2-(phenylseleno)prop-2-enenitrile [CH2 = C(SePh)CN]123,124, phenyl a-phenylselenovinyl sulphone [CH2 = C(SePh)-S02Ph]124 and phenyl a-bromovinyl sulphone124. An electrophilic allene, phenylsulpho-nylpropadiene, has also been used to alkylate enamines125 (Scheme 44). 

Indanyl)-phenol 16 was obtained by reacting p-methoxy-phenyl-acetic acid ethyl ester with benzylchloride to form a-benzyl-p-methoxyphenyl ethyl acetate, saponification into the acid, conversion of the acid with thionylchloride into the chloride, cyclization to 2-p-methoxy-phenyl-l-indanone, NaBH4 reduction to 2-p-methoxyphenyl-l-indanole, dehydration with p-toluene-sulphonic acid in toluene to 2-p-methoxyphenyl-indene, catalytic hydrogenation to 2-p-methoxyphenyl-indene, and treating the ether with HBr [Eq. (5)]. 

Electron Diffraction.—Among completed electron-diffraction studies are ethyl methyl sulphide, chloromethyl methyl sulphide, methyl phenyl sulphide, di-(2-pyridyl) sulphide, sulphones, sulphoxides and sulphones, and trifluoro-methanesulphonyl chloride. A number of precise analyses of gas-phase conformational equilibria have emerged. Methyl ethyl sulphide shows a preference for the gauche conformation rather than for the trans form. ... 

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