Ethyl 2-methoxy-6-methyl benzoat

Ethyl p-methoxy-benzoate Ethyl p-methyl-benzoate Ethyl p-chloro-benzoate... 

CIC Vanillin, the main component in vanilla flavour is the basic key ingredient for the creamy, sweet character. All other volatile flavouring compounds have been identified only in small traces. Among them 2-methoxy phenol and 2-methoxy-4-vinyl phenol are responsible for the phenolic, smoky odour. 4-Methoxy benzalde-hyde, 3,4-methylene-dioxy-benzaldehyde, methyl benzoate and methyl ciimamate impart the warm, powdery, aromatic floral character. Vitispirane adds a fruity, floral topnote. Natural vanilla extract blends very well with other flavourings and it has been modified in different directions ethyl vanillin is used to increase the sweet, creamy vanillin aspect. Tonka beans and coumarin add a full, dried hay, slightly caramel-like custard aspect, supported by the butter notes of diacetyl and 4-hydroxy-decanolide. 

N,N-Diethyl-m-toluidine Dimethyl adipate Dimethylaminopropylamine Dimethyl malonate 1,3-Dinitrobenzene 1,8-Dinitronaphthalene N,N -Diphenyl-p-phenylenediamine Emodin 3-Ethylamino-4-methylphenol 3-Ethylaminophenol Ethyl benzoylacetate Ethylbenzylaniline Ethyl chloride N-Ethyl-N-hydroxyethyl-m-toluidine Ethyl morpholine Hexachlorocyclopentadiene Hexamethyleneimine 1-Hexene Hydrazobenzene Hydroquinone Imidazole Isopropylamine Isopropyl bromide 2-Mercaptoethanol 2-Methoxy-5-nitroaniline Methylamine Methyl anthranilate Methyl benzoate 2-Methyl benzoxazole 4,4 -Methylenedianiline... 

Methoxy-4-methylphenol 202-255-5 2-Phenylpropanal 202-256-0 1-Phenyl-1-propanol 202-257-6 Ethyl phenyl ketone 202-259-7 Methyl benzoate 202-261-8 Methyl nicotinate 202-268-6 Aradur 2844 Casamine 0TB o-Tolyl biguanide 202-280-1 Ablumide SDE Alkamide DS-280 Alkamide DS-280/S Amidex SE Aromide HL-21 Colamid 280 Hetamide DS Jeemide N-1918 Karamide ST-DEA Lipamide S Loramide SD Marvansoft RE-1256 Monamid 718 Nopcogen 14-S Olamida ED Onyxol 42 Protamide SA Stearamide DEA Unamide S Unamide W Upamide SD 202-281-7 Active 18... 

Scheme 9.140. A representation of the process of ester interchange. The methoxy group of methyl benzenecarboxylate (methyl benzoate) is replaced by an ethyoxy group from ethanol (ethyl alcohol, CH3CH20H).The reaction is depicted as the acid-catalyzed substitution of an ethoxy for a methoxy.

Synthesis of Ethyl 4-hydroxy-3,5-bis(((2-methoxy ethyl) (pyridin-2-ylmethyl)amino)methyl)benzoate (C02EtHL2)... 

By condensation of ethyl 3-chloro-6-hydroxy-4-methoxy-2-methyl-benzoate and 2-chlorophloroglucinol (202)... 

Mebeverine (81), a smooth muscle relaxant, is prepared, i. a., by reacting sodium 3,4-dimethoxy-benzoate (77) with 1,4-dichlorobutane to form chloro-ester 78 which is in turn transformed to the corresponding iodide (79) on heating with Nal in methyl-ethyl ketone. Alkylation of 2-ethylamino-3-p-methoxy-phenylpropane (80) with 79 leads to mebeverine... 

If we compare the acid strengths Ka) of a series of substituted benzoic acids with the strength of benzoic acid itself (Table 26-4), we see that there are considerable variations with the nature of the substituent and its ring position, ortho, meta, or para. Thus all three nitrobenzoic acids are appreciably stronger than benzoic acid in the order ortho para > meta. A methoxy substituent in the ortho or meta position has a smaller acid-strengthening effect, and in the para position decreases the acid strength relative to benzoic acid. Rate effects also are produced by different substituents, as is evident from the data in Table 26-5 for basic hydrolysis of some substituted ethyl benzoates. A nitro substituent increases the rate, whereas methyl and methoxy substituents decrease the rate relative to that of the unsubstituted ester. 

RS, 2RS, 3RS)-3-Hydroxy-2-methyl-1-phenylpentyl benzoate 3s and (1SR, 2RS, 3RS)-1-Ethyl-3-hydroxy-2-methyl-3-phenylpropyl benzoate 3a. To a solution of Ti(OiPr)4 (0.32 mL, 1 mmol) in 1-tert-butoxy-2-methoxy ethane (1.5 mL) was carefully added BuLi (0.64 mL, 1 mmol) in hexane under Ar. After stirring for 30 min at 20°C, ketoalcohol 1 (0.5 mL, 5 mmol) and then Ph-CHO 2 (1 mL, 10 mmol) were added. The solution was stirred for 24 h at 20°C and after usual work up the product was chromatographed (silica gel, hexane iPrOH 95 5) to afford 3 and 3a in ratio 5 95. 

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