Ethyl acetyl acetate

ETHYL ACETYL ACETATE (141-97-9) Forms explosive mixture with air (flash point 135°F/57°C). Incompatible with strong acids, nitrates, oxidizers. 

Synonyms Acetoacetic acid ethyl ester Acetoacetic ester Diacetic ether Diacetyl ether EAA EEA Ethyl acetyl acetate Ethyl acelylacetonate Ethyl benzyl acetoacetate Ethyl 3-oxobutanoate Ethyl 3-oxobulyrate 3-Oxobutanoic acid ethyl ester Classification Aliphatic organic compd. 

Ethyl acetyl acetate Ethyl acetylacetonate. See Ethylacetoacetate... 

Ethyl acetate Ethyl acetyl acetate Methyl ethyl ketone... 

Various 4-, 5-, or 4,5-disubstituted 2-aryIamino thiazoles (124), R, = QH4R with R = 0-, m-, or p-Me, HO C, Cl, Br, H N, NHAc, NR2, OH, OR, or OjN, were obtained by condensing the corresponding N-arylthiourea with chloroacetone (81, 86, 423), dichloroacetone (510, 618), phenacyichloride or its p-substituted methyl, f-butyl, n-dodecyl or undecyl (653), or 2-chlorocyclohexanone (653) (Method A) or with 2-butanone (423), acetophenone or its p-substituted derivatives (399, 439), ethyl acetate (400), ethyl acetyl propionate (621), a- or 3-unsaturated ketones (691), benzylidene acetone, furfurylidene acetone, and mesityl oxide in the presence of Btj or Ij as condensing agent (Method B) (Table 11-17). 

Fig. 13.5. Free energy of hydrolysis versus the raiton of cation to anion bonding strength. Ac = acetyl, acetate, Ph = phenyl, Et = ethyl, ATP = adenosine triphosphate.

Sulfanylalkanoyl amino acids and peptides are prepared by reaction of the (acetyl-sulfanyl)- or (benzoylsulfanyl)alkanoic acids or acid chlorides with a-amino esters or peptide esters, followed by deprotection of the sulfanyl and carboxy groups. 8 101114 16 27 29 For example, the 3-(acetylsulfanyl)alkanoic acids 7 are prepared from the condensation of ethyl (diethoxyphosphoryl) acetate 5 with various aldehydes according to the Horner-Emmons reaction, providing the a, 3-unsaturated ethyl esters 6 (a mixture of Z- and E-isomers, 50 50), followed by saponification of the ethyl esters and Michael addition of thiolacetic acid. The 3-(acetylsulfanyl)alkanoic acids 7 can be coupled with a-amino esters or peptide esters and subsequent hydrolysis of the 3-(acetylsulfanyl) derivatives provides the desired products 8 (Scheme 2). 14 ... 

RX. n-butyl bromide n-dodecanyl iodide cyclohexyl iodide ethyl bromo acetate methyl 2,3-di-O-acetyl-4-O-benzoyl-6-bromo-6-deoxy-ot-D-glucopyranoside methyl 2,3,4-tri-0-acetyl-6-deoxy-6-iodo-0 -D glucopyranoside l,2 3,4-di-0-isopropylidene-6-deoxy-6-iodo-a-D-galactopyranose methyl 2(R)-[(tert-butoxycarbonyl)amino]-3-iodo-propionate cyclic bis(trifluoromethyl)oxazolidinone bromide. 

ACETOACETIC ESTER ACTIVE ACETYL ACETATE DIACETIC ETHER EAA ETHYL ACETOACETATE... 

Acetyl-acetic acid—CH,—CO—CH,—COOH is produced as the ethylic ether of a sodium derivative by the action of metallic Na upon ethyl acetate. The acid itself may be obtained as a very unstable, acid liquid, soluble in water in all proportions. It is the type of a great number of similarly constituted acids, containing other radicals and their derivatives, and is extensively used in the preparation of synthetic products of great variety, as, for instance, in the manufacture of antipyrin (q. v.). 

The side chain is prepared by the interaction between either ethylene oxide or l-chloro-2-hydroxy ethane with diethyl amine in methanol yields 2-hydroxy-triethyl hydrochloride. This on chlorination with thionyl chloride yields 2-chloro-triethyl amine whieh on treatment with ethyl aceto-acetate in the presence of sodium ethoxide gives an intermediate eompound. Alkaline hydrolysis produces l-acetyl-3-diethylamino propane which on reduction with Raney Nickel followed by oximation yields 4-amino-1-diethylamino pentane. 

The hydrochloride of the Wieland-Gumlich aldehyde is converted by boiling ethanol into the single ethyl acetal XIV (R = OEt). Diaboline hydrochloride is similarly converted into an acetal XV (R = OEt) which is also formed by acetylation (acetic anhydride in pyridine) of XIV (R = OEt). Consideration of the chemical shifts of the 0-17 protons in these acetals and of rotation shifts indicates the stereochemistry shown i.e., the acetal possesses the same configuration as the corresponding hemiacetal. 

Acetyl pantothenyl ethyl ether. See Panthenyl ethyl ether acetate... 

Synonyms Ethyl 2-acetal-3-phenylpropionate Ethyl a-acetylhydrocinnamate Ethyl a-acetyl hyd roxyci n n am ate Ethyl benzyl acetoacetate Ethyl-3-oxo-2-benzylbutanoate... 

See 2-Ethyl hexyl acetate Ethyl-2-hexyl acetoacetate Ethyl a-hexylacetoacetate. See Acetyl ethyl octanoate 2-Ethyl hexyl 12-(acetoxy) octadecanoate 2-Ethylhexyl 12-acetoxyoctadecanoic acid. See Octyl acetoxystearate... 

Trade Name Synonyms Humectant SD-35 t[Presperse http //www.presperse.com], SD-35 t[Presperse http //www.presperse.com] Panthenyl ethyl ether acetate Synonyms Acetyl pantothenyl ethyl ether Butanamide, 2-hydroxy-4-acetyloxy-3,3-dimethyl-N-(3-ethoxypropyl)-Definition Ester of acetic acid and the ethyl ether of panthenol Empirical C13H26NOS Formula ... 

Acetaldehyde ethyl phenethyl acetal Acetaldehyde phenethyl propyl acetal Acetanisole Acetic acid, (cyclohexyloxy)-, 2-propenyl ester Acetisoeugenol 2 -Acetonaphthone Acetophenone Acetyl butyryl Acetylcyclopentanone Acetyl ethyl octanoate... 

Pentane-2,4-dione reacts with 3-chloro-l,2-benzisothiazole in the presence of sodium ethoxide to form 2-acetyl-3-aminobenzo[6]thiophen (71%). Under similar conditions, ethyl acetoacetate and diethyl malonate each give mainly ethyl 3-aminobenzo[6]thiophen-2-carboxylate (160). Under modified conditions diethyl malonate gives, in addition, some of the expected diethyl (l,2-benzisothiazol-3-yl)malonate, whereas ethyl cyano-acetate forms only ethyl (l,2-benzisothiazol-3-yl)cyanoacetate, irrespective of conditions. Mechanisms were considered involving iS-substituted o-cyanothiophenols as possible intermediates in the reactions leading to benzo[6]thiophen (see Scheme 8). The reactions constitute a useful... 

The enzyme is specific for thiol esters of the type of S-acetyl and S-butyryl glutathione. Besides the three thiol esters already discussed, ethyl thiol-acetate, butyl thiolacetate, acetyl thioglycolic acid, acetyl mercapto propionic acid, S-acetyl-2 mercaptoethanol, acetyl thiomalic, acetyl coenzyme A, and butjryl coenzyme A were inactive with the purified enzyme. Crude extracts of liver attacked butyl thiolacetate and acetyl coenzyme A slowly. 

Mixtures of O-methyl ethers obtained by partial methylation of a number of methyl glycopyranosides have been acetylated and the products identified by g.l.c.-m.s. The use of partially ethylated alditol acetates for the analysis by g.I.c. of the components of polysaccharides has been described. The ethyl analogues are eluted before the corresponding methyl derivatives, and this often allows the separation of many polysaccharide components by g.l.c. that are not separable as their partially methylated alditol acetates. The use of molar flame-responses calculated on the basis of effective carbon responses has been advocated for the accurate determination of partially methylated and partially ethylated alditol acetates by g.I.c. ... 

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