4- Ethoxycarbonyl-5-hydroxy-2-methyl

Indazole, 5,5-dimethyl-3-trifluoromethyl-4,5-dihydro-trichomonacidal activity, 5, 291 Indazole, 2-ethoxycarbonyl-reactions, 5, 269 Indazole, 3-fluoro-synthesis, S, 263 Indazole, 1-germyl-synthesis, 5, 236 Indazole, 1-glycosyl-synthesis, 5, 289 Indazole, 2-glycosyl-synthesis, 5, 289 Indazole, halo-reactions, S, 266 Indazole, 2-hydroxy-methylation, 5, 269 Indazole, 3-hydroxy-reactions, S, 264 Indazole, 6-hydroxy-diazo coupling, 5, 86 Indazole, hydroxyphenyl-synthesis, S, 288 Indazole, 3-iodo-synthesis, S, 241 Indazole, l-isopropyl-3-phenyl-reduction, 5, 243 Indazole, 3-mercapto-1 -substituted tautomerism, 5, 265 Indazole, methoxy-... 

Thiazole, 5-amino-4-ethoxycarbonyl-2-methyl-synthesis, 6, 306 Thiazole, 2-amino-4-(2 -furyl)-bromination, 6, 256 Thiazole, 2-amino-4-hydroxy-synthesis, 6, 296 Thiazole, 5-amino-2-hydroxy-synthesis, 6, 301 Thiazole, 5-amino-2-mercapto-synthesis, 6, 301 Thiazole, 2-amino-4-methyl-alkylation, 6, 256 synthesis, 6, 300 Thiazole, 2-amino-5-nitro-antiparasitic activity, 1, 180... 

Treatment of alkyl 9-benzyloxycarbonyl-3-methyl-6-oxo-2/7,6//-pyr-ido[2,l-f ][l,3]thiazine-4-carboxylates with BBr3 in CH2CI2 at -70 °C for 0.5-1 h and at room temperature for 3h yielded 9-carboxyl derivatives. The decarboxylation of these acids was unsuccessful. Hydrolysis of diethyl cA-3,4-H-3,4-dihydro-3-methyl-6-oxo-2//,6//-pyrido[2,l-f ][l,3]thiazine-4,9-dicarboxylate in aqueous EtOH with KOH at room temperature for 3 days yielded 4-ethoxycarbonyl-3,4-dihydro-3-methyl-6-oxo-2//,6//-pyrido-[2,l-f ] [1,3]thiazine-9-carboxylic acid (00JCS(P1)4373). Alkyl 9-hydroxy-methyl-3-methyl-6-oxo-3,4-dihydro-2//,6//-pyrido[2,l-f ][l,3]thiazine-4-car-boxylates were O-acylated with AC2O and (PhC0)20 in pyridine at room temperature for 12-48h. 

Dimethylquinoxaline (147) gave 2-ethoxycarbonyl-2-hydroxy -methyl-2,3-dihydro-[l/ ]-pyrrolo[l,2-u]quinoxalin-10-ium bromide (148) (BrCH2CO-C02Et, AcEt, reflux, 3h, then 20°C, 12 h 72%) and thence successively ethyl 4-methylpyrrolo[l,2-fl]quinoxaline-2-carboxylate (149) (EtONa, EtOH, 20°C, 4h 93% note oxidation by loss of H2O), the uncharacterized quaternary salt (150) (as the first step but 6h 50%), and diethyl dipyr-rolo[l,2-fl 2, l -c]quinoxaline-2,ll-dicarboxylate (151) (KOH, H2O, reflux, 1 h 56%). ° " - ... 

Of interest is also that the rate of liberation of penicillin G from the prodrug was much faster than the breakdown of the former by opening of its /3-lactam ring. Furthermore, no breakdown of the pro-moiety A-(hydroxy-methyl)-A-[(ethoxycarbonyl)methyl]benzamide (8.58) to liberate formaldehyde was detected over the timescale of ester hydrolysis. 

Mit Lithiumalanat werden 5-Ethoxycarbonyl-2,4-difluor-l-(methoxy-methyl)-imidazol zu 4-Fluor-4-hydroxy methyl-1-(methoxy-methyl)-imidazol499 und l-(2,6-Dimethyl-phenyl)-5-fluor-2-phenyl-4-trifluormethyl-imidazol zu l-( 2,6-Dimethyl-pheny )-2-phenyl-4-trifluormethyl-imid-azol927 reduziert. 

Ein analoger Reaktionsweg wird bei der Cyclisierung des N-Aryl-nitrons IV mit Bromcyan zu I-(Ethoxycarbonyl-imino-methyl)-2-hydroxy-benzimidazol(66% Schmp. 127-132°) beobachtet591 ... 

Bei der Reaktion von 2-Ethoxycarbonyl-6-methyl-piperidin mit Oxiran in Methanol bei 100° im Dmckgefafl bildet sich uber N-(2-Hydroxy-alkylierung) und Cyclokondensation 10-Methyl-5-oxo-4-oxa-l-aza-bicyclo[4.4.0]decan, das sich mittels Lithium-alanat reduktiv zu l-(2-Hydroxy-ethyl)-2-hydroxymethyl-6-methyl-piperidin spalten laBt2. 

Carbamidsanre N-(l-Hydroxy-2,2,2-trifluor-ethyl)- -(4-methoxy-benzylester) E14a/2, 60 (R-CHO/RO-CO-NH2) Pyrrol 4-Acetyl-2-ethoxycarbonyl-5-methyl-3-trifluormethyl-E6a, 625 (F3C-CO-CH2-COOR + HN02 2,4-Pentandion/Zn)... 

Ethoxycarbonyl-5-methyl-4-phenyl-2,3-dihydro-l,4-thiazin reagiert mit 80%igem Hydrazin-Hydrat (Ethanol lh RiickfluB) zu 4-(2-Anilino-ethylthio)-3(5)-hydroxy-5(3)-phenyl-lH-pyrazol (Schmp. 181-182< )1588a s-a-1589... 

BenZoylamino-thiocarbonyl)-ethoxycarbonyl-methyll-4-hydroxy- 8 2-Benzoyl-3-benzyl-5-ethoxycarbonyl-4-methyl-2,3-dihydro- 356 5-Benzoyl-2,4-bis-[4-methoxy-phcnyl]-aus 4-Methoxy-N-(4-methoxy-a-morpholino-bcnzyliden)-thio-benzamid und -Brom-aceto-phcnon 135 5-Benzoyl-2-chlor- 263... 

Diisopropyloxyphosphoryl-hydroxy-methyl)-2-ethoxycarbonyl-4-cthyl- 202 5-(Diisopropyloxyphosphoryl-methyl)-2,4-dimethyl- 89... 

Amino-4-ethoxycarbonyl-5(3)-hydroxy- 464 3-Amino-4-ethoxycarbonyl-l-methyl- 643 5-Amino-4-cthoxycarbonyl-1 -methyl- 465... 

Ethoxycarbonyl-3-methyl- 780 Struktur 765 3-Hydroxy-3-phenyl- 784 3-Imino- 765 (Struktur)... 

Dimethyl-8-ethoxycarbonyl-5-hydroxy-2-oxo-2H-378 Eine Mischung aus 2g (0,01 mol) 4,6-Dihydroxy-3-ethoxycarbonyl-2-methyl-pyridin und 1,3 g (0,01 mol) 3-Amino-2-butensaure-ethylester wird 30 Min. auf 220° erhitzt. Den freiwerdenden Alkohol und Ammoniak laBt man durch ein kurzes Steigrohr entweichen. Nach 15 Min. erstarrt der Ansatz. Das Rohprodukt kristallisiert beim Anreiben mit Petrolether und Ether. Aus Xylol erhalt man farblose Nadeln Ausbeute 2,5 g (95%) Schmp. 265-270". 

When large groups, such as phenyl, bromo, ethoxycarbonyl or nitro are attached at position 3, the principal products are l-alkylcinnolin-4(l/f)-ones. Cyanoethylation and acetylation of cinnolin-4(l/f)-one takes place exclusively at N-1. Phthalazin-l(2/f)-ones give 2-substituted derivatives on alkylation and acylation. Alkylation of 4-hydroxyphthala2in-l(2/f)-one with an equimolar amount of primary halide in the presence of a base leads to 2-alkyl-4-hydroxyphthalazin-l(2/f)-one and further alkylation results in the formation of 4-alkoxy-2-alkylphthalazinone. Methylation of 4-hydroxy-2-methyl-phthalazinone with dimethyl sulfate in aqueous alkali gives a mixture of 4-methoxy-2-methylphthalazin-l(2/f)-one and 2,3-dimethylphthalazine-l,4(2//,3//)-dione, whereas methylation of 4-methoxyphthalazin-l(2/f)-one under similar conditions affords only 4-methoxy-2-methylphthalazinone. 

Selenophene, 2,5-dimethyl-3-mercapto-synthesis, 4, 956 tautomerism, 4, 946 Selenophene, 2,4-diphenyl-synthesis, 4, 135 Selenophene, 2,5-diphenyl-lithiation, 4, 949 UV spectra, 4, 941 Selenophene, 2-ethoxycarbonyl-mercuration, 4, 946 Selenophene, halo-reactions, 4, 955 Selenophene, 2-hydroxy-Michael reaction, 4, 953 tautomerism, 4, 36, 945, 953 Selenophene, 3-hydroxy-tautomerism, 4, 36, 945 Selenophene, 3-hydroxy-2,5-dimethyl-tautomerism, 4, 945, 953 Selenophene, 2-hydroxy-5-methyl-methylation, 4, 953 tautomerism, 4, 945 Selenophene, 2-hydroxy-5-methylthio-tautomerism, 4, 945 Selenophene, 3-iodo-synthesis, 4, 955 Selenophene, 3-lithio-reactions, 4, 79 synthesis, 4, 955 Selenophene, 2-mercapto-tautomerism, 4, 38 Selenophene, 3-mercapto-tautomerism, 4, 38 Selenophene, 2-mercapto-5-methyl-synthesis, 4, 956 tautomerism, 4, 946 Selenophene, 3-methoxy-lithiation, 4, 949, 955 synthesis, 4, 955 Selenophene, methyl-oxidation, 4, 951 synthesis, 4, 963 Selenophene, 2-methyl-lithiation, 4, 949 Selenophene, 3-methyl-synthesis, 4, 963... 

C20H27NO4 58/75-90-5) see Butorphanol 3-ethoxycarbonyl-4-hydroxy-2-methyl-2H-l,2-benzothia-zine 1,1-dioxide... 

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