Ethnic factors efficacy response

Efficacy Nine topic headings—Clinical Safety, Clinical Study Reports, Dose-Response Studies, Ethnic Factors, GCP, Clinical Trials, Clinical Evaluation by Therapeutic Category, Clinical Evaluation, Pharmacogenomics total of 18 guidelines... 

To conclude, this sampling of the literature of risk perception, the comments of Covello, 1981 may be summarized. Surveys have been of small specialized groups - generally not representative of the population as a whole. There has been little attempt to analyze the effects of ethnicity, religion, sex, region age, occupation and other variables that may affect risk perception. People respond to surveys with the first thing that comes to mind and tend to stick to this answer. They provide an answer to any question asked even when they have no opinion, do not understand the question or have inconsistent beliefs. Surveys are influenced by the order of questions, speed of response, whether a verbal or numerical respon.se is required and by how the answer is posed. Few Studies have examined the relationships between perceptions of technological hazards and behavior which seems to be influenced by several factors such as positive identification with a leader, efficacy of social and action, physical proximity to arenas of social conflict. 

Recent haplotype-phenotype studies have also indicated that the genetic relevance to toxic events varies depending on ethnicity and regimen. On this point, it must be noted that lAl 6 in East-Asians is also an important risk factor for severe neutropenia. In contrast, the effects of UGTIA genotypes on the anti-tumor responses to irinotecan treatment remain imclear. Therefore, further clinical studies are needed to evaluate the benefits of the genotyping of 28 and 6 or other markers in terms of irinotecan efficacy. 

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