Ether, Acetal, and Ester Derivatives

A review on the use of protecting groups derived from organosilicon reagents includes a discussion of the protection of 1,2- and 1,3-diols many examples from carbohydrate and nucleoside chemistry are included,  

Routes have been described for the synthesis of N-acyl-2 -0- 

A similar achiral, acid-labile protecting group has been employed in oligonucleotide synthesis this is the 3-methoxy-1,5-dicarbo-methoxypentanyl (MDMP) group (51), which when present at the 2 - 

Interaction of a ribonucleoside with dibromomethane under phase-transfer conditions gave 23 - -methylene acetals. In the case of the uridine derivative, glycosyl cleavage occurred in acid before complete deprotection, and, since purine nucleosides are more labile, methylene acetals are unlikely to be of any practical 

Improved, high-yielding procedures have been given for the 

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Carbocyclic Nucleoside Analogues Nucleoside Phosphates and Phosphonates Ether, Acetal, and Ester Derivatives Miscellaneous Nucleoside Analogues Reactions... 

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