Estradiol, structure and function

Fricker, G., Landmann, L., Meier, P.J. Ethinyl-estradiol-induced structural and functional alterations of rat liver plasma membrane and their reversal by SAME in vitro. Hepatology 1988 8 1224. 

Diethylstilbesterol (DES) (Stilphostrol) Nonsteroidal estrogen. All drugs above are steroids. Equal in potency to estradiol. Previously used by pregnant women to prevent threatened abortion. The reproductive systems of children born to DES-exposed mothers are more likely to be structurally and functionally abnormal (yearly genital exams are encouraged). Slow metabolism allows oral, topical, or IV administration at wider dosing intervals than most other preparations. 

Therapeutic Function Estrogen Chemical Name Estradiol phosphate polymer Common Name Polymeric ester of phosphoric acid and estradiol Structural Formula r... 

Treatment of A 8(9)-dehydroestradiol with trifhioroacetic acid and triethylsilane gives estradiol in 96% yield (Eq. 86).239 The 3-methyl ether is similarly reduced to the 3-methyl ether of estradiol in >50% yield.239 The structurally related 18-ethyl and 18-propyl 17-keto compounds experience reduction of the A8(9) function in excess of 70% yield without concomitant reduction of the 17-keto... 

Of the numerous hormones that regulate body function, two steroid hormones are extremely important estradiol, a female sex hormone and testosterone, a male sex hormone. Present in the body in insignificant amounts, they regulate sexual differentiation and reproduction as well as affect the performance of many other physiological systems. Despite the great similarity in chemical structure, they are very different in terms of physiological action. 

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