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Estradiol chemical delivery system

M. E. Brewster, K. E. Estes, T. Loftsson, R. Perchalski, H. Derendorf, G. Mullers-man, and N. Bodor, Improved delivery through biological membranes. XXXI. Solubilization and stabilization of an estradiol chemical delivery system by modified P-cyclodextrins, J. Pharm. Sci. 77 981 (1988). [Pg.192]

W. R. Anderson, J. W. Simpkins, M. E. Brewster, and N. Bodor, Evidence for the reestablishment of copulatory behavior in castrated male rats with a brain-enhanced estradiol-chemical delivery system, Pharmacol. Biochem. Behav. 27 265 (1987). [Pg.192]

J. W. Simpkins, W. R. Anderson, R. Dawson, Jr., and N. Bodor, Effects of a brain-enhanced chemical delivery system for estradiol on body weight and food intake in intact and ovariectomized rats, Pharrn. Res. 6 592 (1989). [Pg.193]

Millard, W. J., Romano, T. M., Bodor, N., Simpkins, J. W. Growth hormone (GH) secretory dynamics in animals administered estradiol utilizing a chemical delivery system. Pharm. Res. 1990, 7, 1011-1018. [Pg.836]

Tissue targeting may also be directed at tumors through the use of monoclonal antibodies, as briefly mentioned earlier. Finally, brain targeting can also be attempted with the prodrug approach, as exemplified by estradiol by use of a redox-based chemical delivery system (174). [Pg.515]

Brewster, M.E. Druzgala, P.J. Anderson, W.R. Huang, M.-J. Bodor, N. Pop, E. Efficacy of a 3-substi-tuted versus 17-substituted chemical delivery system for estradiol brain targeting. J.Pharm.Sci., 1995, 84, 38-43... [Pg.560]

Estradiol transdermal system is designed to deliver 17(beta)-estradiol continuously and consistently over a 3-or 4-day interval on application to intact skin. Three strengths of Alora systems are available, having nominal in vivo delivery of 0.05, 0.075, and 0.1 mg estradiol per day through skin of average permeability (interindividual variation in skin permeability is approximately 20%). Alora systems have contact surface areas of 18, 27, and 36 cm2 and contain 1.5, 2.3, and 3.0 mg of estradiol USP, respectively. The composition of the systems per unit active surface area is identical. Estradiol USP [17(beta>-estradiol] is a white, crystalline powder that is chemically described as estra-l,3,5(10)-triene-3,17(beta)-diol, has an empirical formula of and has a molecular... [Pg.155]

See other pages where Estradiol chemical delivery system is mentioned: [Pg.193]    [Pg.835]    [Pg.187]    [Pg.669]    [Pg.835]    [Pg.186]    [Pg.818]    [Pg.180]    [Pg.653]    [Pg.818]    [Pg.203]    [Pg.3846]    [Pg.241]   
See also in sourсe #XX -- [ Pg.2 , Pg.583 , Pg.584 , Pg.585 ]



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Estradiol

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