Esophageal reflux, chest pain

Proton pump inhibitors (PPIs), such as omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole, are commonly prescribed to treat symptoms of heartburn, acid reflux, chest pain, dyspepsia, and chronic cough. PPIs inhibit the transfer of protons into the stomach lumen. Pharmacological acid suppression is thus used to treat gastroesophageal reflux disease (GERD) and esophagitis, peptic ulcers, and Helicobacter pylori infection as well as to prevent ulcer development with concurrent nonsteroidal anti-inflammatory drug use. 

Observational studies In an open study of rabeprazole 20 mg/day for 8 weeks in 2579 patients with gastroesophageal reflux disease and endoscopically confirmed erosive esophagitis, there was substantial symptomatic relief [74 ]. The most common adverse events included abdominal pain (1.2%), chest pain (0.5%), diarrhea (1.5%), dizziness (0.7%), dyspepsia (0.6%), belching (0.5%), headache (1.6%), nausea (1.0%), rashes (0.5%), and upper respiratory tract infections (0.5%) 15% of patients reported at least one adverse event, 2.4% withdrew because of adverse events, and 1.4% reported a serious adverse event. All the serious adverse events were considered to... 

An eighteenth-century British cartoon accurately attests to the wide public awareness and familiarity with the "Demon of Dyspepsia. Confusion as to the source of visceral pain led to the evolution of a nomenclature that confused the origin of the symptoms with the stomach, the heart, or even the brain. Many believed all chest symptoms emanated from the heart, and reflux symptoms were referred to as cardiodynia or cardalgia Indeed, two centuries later, the basis of esophageal pain is as little understood now as it was then ... 

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