Esomeprazole magnesium

Nexium (esomeprazole magnesium, AstraZeneca) is a drug termed as a proton pump inhibitor. It turns off the secretions of acid into the stomach. When less acid is produced, there is a reduced amount of acid that can flow back up from the stomach into the esophagus to cause reflux symptoms. 

The large-scale production of esomeprazole is now successfully achieved by asymmetric oxidation of the same sulfide intermediate as is used in the production of omeprazole (Scheme 2.5). Using the titanium-based catalyst originally developed by K. Barry Sharpless for allyl alcohol oxidation [56] and by H.B. Kagan for certain sulfide oxidations [57], a process was developed that could achieve initial enantiomeric excesses of about 94% [53]. During the production process, the optical purity is further enhanced by the preparation of esomeprazole magnesium salt, with subsequent re-crystallization. 

Astra-Zeneca s omeprazole (Losec) (approximately 50 per 28 20-mg tablets down from over 100 in 2001 when its turnover was some 6 billions ll its esomeprazole magnesium (Nexium) ( 202 per 30 20-mg tablets) are having their market positions eroded by generic omeprazole ( 55 per 56 20-mg tablets) and OTC Prilosec (omeprazole) ( 20 per 28 20-mg tablets). 

Indication Omeprazole Lansoprazole Pantoprazole Sodium Rabeprazole Sodium Esomeprazole Magnesium... 

Nexium (Esomeprazole magnesium). AstraZeneca. US Prescribing information, Ap 2007. 

Nexium Tablets (Esomeprazole magnesium trihydrate). AstraZeneca UK Ltd. UK Summary of product characteristics, May 2007. 

Datto C, Hellmund R, Siddiqui MK. Efficacy and tolerability of naproxen/esomeprazole magnesium tablets compared with non-specific NSAlDs and COX-2 inhibitors a systematic review and network analyses. Open Access Rheumatol Res Rev 2013 5 1-19. 

Figure 1.19 Xopenex (levalbuterol), Prozac (fluoxetine), and Nexium (esomeprazole, actually a magnesium salt of the compound shown).

Another four patients, two men aged 63 and 81 years and two women aged 73 and 62 years, who had been using a proton pump inhibitor (esomeprazole, pantoprazole, omeprazole, or rabeprazole, 20-40 mg/day) for 1-13 years, developed severe hypomagnesemia with hypocalcemia, relative hypoparathyroidism, and extremely low urinary calcium and magnesium excretion [52 ]. One was admitted with postanoxic encephalopathy after a collapse probably caused by a dysrhythmia. The others had electrocardiographic abnormalities... 

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