Naproxen Esomeprazole

The antiplatelet activity and the pharmacokinetics of aspirin do not appear to be affected by omeprazole. There was no clinically relevant pharmacokinetic interaction between omeprazole and diclofenac, enteric-coated ketoprofen, naproxen or piroxicam, or between pantoprazole and diclofenac or naproxen, or between esomeprazole and naproxen or rofecoxib. 

Naproxen 250 mg twice daily given to healthy subjects with omeprazole 20 mg daily, pantoprazole 40 mg daily, or esomeprazole 40 mg daily for one week had no effeet on the pharmacokinetics of either naproxen or the proton pump inhibitor. 

Hassan-Alin M, Naesdal J, Nilsson-Pieschl C, Langstrom G, Andersson T. Lack of pharmacokinetic interaction between esomeprazole and the nonsteroidal anti-inflammatory drugs naproxen and rofecoxib in healthy subjects. Clin Drug Invest (2005) 25, 731-40. 

Datto C, Hellmund R, Siddiqui MK. Efficacy and tolerability of naproxen/esomeprazole magnesium tablets compared with non-specific NSAlDs and COX-2 inhibitors a systematic review and network analyses. Open Access Rheumatol Res Rev 2013 5 1-19. 

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