Escherichia coli arginine biosynthesis

M. Ginesy, J. Belotserkovsky, J. Enman, L. Isaksson, U. Rova, Metabolic engineering of Escherichia coli for enhanced arginine biosynthesis, Microb. CeU Fact. 14, 1-11 (2015). 

Let us begin by examining arginine biosynthesis in Escherichia coli (Fig. 2). Natural selection puts a premium on the efficiency with which bacteria can utilize nutrients for growth and has thus led to the emergence of mechanisms for the feedback control of biosynthetic pathways. 

Low, K.B., and Canellakis, E.S. (1987) Biosynthesis of polyamines in ornithine decarboxylase, arginine decarboxylase, and agmatine ureohydrolase deletion mutants of Escherichia coli strain K-12. Proc. Natl Acad. Sci. USA., 84 (13), 4423 -4427. 

Fig. 29. Arrangement of loci of enzymes of arginine biosynthesis in the chromosome of Escherichia coli K-12 (Gorini et al., 1961). The crossover time for movement of the chromosome from one cell to another is 22-23 min for ARG5, 25-28 or 34-35 min for ARG4, 36-37 min for ARG2, 55-59 min for ARG6 or 7, and 68 min for ARGl. LAC markers are transferred after 18 min and HIS after 70 min.

Celis, T. F. R., Maas, W. K. Studies on the mechanism of repression of arginine biosynthesis in Escherichia coli. IV. Further studies on the role of arginine transfer RNA repression of the enzymes of arginine biosynthesis. J. molec. Biol. 62, 179-188... 

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